Mohammadzadeh Nooshin, Mehri Soghra, Hosseinzadeh Hossein
School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran.
Pharmaceutical Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.
Iran J Basic Med Sci. 2017 May;20(5):538-551. doi: 10.22038/IJBMS.2017.8678.
L () and its main constituent berberine have been used in traditional medicine for a long time. This medicinal plant and berberine have many properties that have attracted the attention of researchers over the time. According to several studies, and berberine exhibited anti-inflammatory, antioxidant, anticonvulsant, antidepressant, anti-Alzheimer, anti-cancer, anti-arrhythmic, antiviral, antibacterial and anti-diabetic effects in both and experiments. In regard to many reports on protective effects of and berberine on natural and chemical toxins, in the current review article, the inhibitory effects of these compounds against natural, industrial, environmental and chemical toxicities with focus on cellular mechanism have been categorized. It has been mentioned that berberine could ameliorate toxicity of chemical toxins in brain, heart, kidney, liver and lung in part through antioxidant, anti-inflammatory, anti-apoptotic, modulation of mitogen-activated protein kinase (MAPK) and nuclear factor-κB (NF-κB) signaling pathways.
黄连及其主要成分小檗碱长期以来一直用于传统医学。随着时间的推移，这种药用植物和小檗碱具有许多特性，吸引了研究人员的关注。根据多项研究，黄连和小檗碱在体内和体外实验中均表现出抗炎、抗氧化、抗惊厥、抗抑郁、抗阿尔茨海默病、抗癌、抗心律失常、抗病毒、抗菌和抗糖尿病作用。鉴于关于黄连和小檗碱对天然毒素和化学毒素保护作用的许多报道，在当前的综述文章中，这些化合物对天然、工业、环境和化学毒性的抑制作用（重点是细胞机制）已被分类。据提到，小檗碱可部分通过抗氧化、抗炎、抗凋亡、丝裂原活化蛋白激酶（MAPK）和核因子-κB（NF-κB）信号通路的调节来改善化学毒素在脑、心、肾、肝和肺中的毒性。
