IFR Santé-STIC, UFR de Médecine et Pharmacie, Laboratoire de Physiopathologie et Pharmacologie Cardiovasculaires Expérimentales (LPPCE), Université de Bourgogne, 7, Boulevard Jeanne-d'Arc, 21000 Dijon, France.
Arch Cardiovasc Dis. 2010 Aug-Sep;103(8-9):454-9. doi: 10.1016/j.acvd.2010.08.002. Epub 2010 Oct 25.
Telomeres are structures composed of deoxyribonucleic acid repeats that protect the end of chromosomes, but shorten with each cell division. They have been the subject of many studies, particularly in the field of oncology, and more recently their role in the onset, development and prognosis of cardiovascular disease has generated considerable interest. It has already been shown that these structures may deteriorate at the beginning of the atherosclerotic process, in the onset and development of arterial hypertension or during myocardial infarction, in which their length may be a predictor of outcome. As telomere length by its nature is a marker of cell senescence, it is of particular interest when studying the lifespan and fate of endothelial cells and cardiomyocytes, especially so because telomere length seems to be regulated by various factors notably certain cardiovascular risk factors, such as smoking, sex and obesity that are associated with high levels of oxidative stress. To gain insights into the links between telomere length and cardiovascular disease, and to assess the usefulness of telomere length as a new marker of cardiovascular risk, it seems essential to review the considerable amount of data published recently on the subject.
端粒是由脱氧核糖核酸重复序列组成的结构，可保护染色体的末端，但会随着每次细胞分裂而缩短。它们已经成为许多研究的主题，特别是在肿瘤学领域，最近它们在心血管疾病的发生、发展和预后中的作用引起了相当大的兴趣。已经表明，这些结构可能在动脉粥样硬化过程开始时、动脉高血压的发生和发展期间或心肌梗死期间恶化，其长度可能是预后的预测指标。由于端粒长度本质上是细胞衰老的标志物，因此在研究内皮细胞和心肌细胞的寿命和命运时特别有趣，特别是因为端粒长度似乎受到各种因素的调节，特别是某些心血管危险因素，如吸烟、性别和肥胖，这些因素与高水平的氧化应激有关。为了深入了解端粒长度与心血管疾病之间的联系，并评估端粒长度作为心血管风险的新标志物的有用性，似乎必须回顾最近就该主题发表的大量数据。
