线粒体解偶联蛋白基因簇变异（UCP2-UCP3）与 2 型糖尿病发病风险：女性基因组健康研究。
Mitochondrial uncoupling protein gene cluster variation (UCP2-UCP3) and the risk of incident type 2 diabetes mellitus: the Women's Genome Health Study.
机构信息
Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02215, USA.
出版信息
Atherosclerosis. 2011 Jan;214(1):107-9. doi: 10.1016/j.atherosclerosis.2010.10.016. Epub 2010 Oct 20.
Abstract
OBJECTIVE
Uncoupling protein 2, mitochondrial, (UCP2) gene variation has recently been implicated in type 2 diabetes mellitus (T2DM). To date, no prospective epidemiological data are available.
METHODS
The association between 14 UCP (UCP2-UCP3) gene cluster tagging-SNPs and incident T2DM was investigated in 22,715 Caucasian participants of the prospective Women's Genome Health Study. All were free of known cardiovascular disease and diabetes at baseline. During a 13-year follow-up period, 1445 participants developed an incident T2DM. Multivariable Cox regression analysis was performed to investigate the relationship between genotypes and T2DM risk assuming an additive model. Stratified analysis by smoking status, and haplotype analysis were also performed.
RESULTS
No evidence for an association of any of the tagging-SNPs tested with T2DM risk. Further investigation using stratified analysis, and haplotype-based approach showed similar null findings.
CONCLUSION
The present investigation suggests that the UCP gene cluster variation may not be useful predictor for T2DM risk assessment.
摘要
目的
解偶联蛋白 2，线粒体（UCP2）基因变异最近与 2 型糖尿病（T2DM）有关。迄今为止，尚无前瞻性的流行病学数据。
方法
在前瞻性妇女基因组健康研究的 22715 名白种人参与者中，研究了 14 个 UCP（UCP2-UCP3）基因簇标记-SNPs 与新发 T2DM 的关联。所有参与者在基线时均无已知的心血管疾病和糖尿病。在 13 年的随访期间，1445 名参与者发生了新发 T2DM。采用多变量 Cox 回归分析，假设加性模型，研究基因型与 T2DM 风险之间的关系。还进行了按吸烟状况分层的分析和基于单体型的分析。
结果
没有证据表明所测试的任何标记-SNPs 与 T2DM 风险有关。使用分层分析和基于单体型的方法进一步调查显示了类似的阴性结果。
结论
本研究表明，UCP 基因簇的变异可能不是 T2DM 风险评估的有用预测因子。
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