Jun H S, Kim In K, Lee H J, Lee H J, Kang Jae H, Kim J R, Shin Hyoung D, Song J
Division of Metabolic Diseases, Center for Biomedical Sciences, Korean National Institute of Health, Seoul, Republic of Korea.
Obesity (Silver Spring). 2009 Feb;17(2):355-62. doi: 10.1038/oby.2008.531. Epub 2008 Nov 27.
To investigate the associations of uncoupling protein (UCP)2 and UCP3 gene variants with overweight and related traits, we genotyped UCP2-866G>A, UCP2Ala55Val, and UCP3-55C>T in 737 Korean children and 732 adults and collected data regarding anthropometric status and blood biochemistry. Information concerning the children's lifestyles and dietary habits was collected. The UCP2-866G>A and UCP3-55C>T gene variants showed significant associations with BMI level, waist circumference, and body weight in the children but not in the adults. Compared with -866GG carriers, the -866GA and AA carriers showed a strong decreasing trend in the risk for overweight (odds ratio (OR), 0.67; 95% confidence interval (CI), 0.45-1.01; P = 0.053). In comparison with UCP3-55CC carriers, children carrying -55CT and TT showed a significant reduction in the risk of overweight (OR, 0.67; 95% CI, 0.46-0.98; P = 0.039). There was also evidence of interactions between the effects of the combined UCP2-UCP3 genotype and obesity-related metabolic traits. The greatest protective effect against overweight was seen in those with the combined genotype non-UCP2-866GG and non-UCP3-55CC, as compared with those carrying both UCP2-866GG and UCP3-55CC (OR,0.60; 95% CI, 0.38-0.95; P = 0.030). In the subgroup with a low level of physical activity, UCP3-55CC carriers had higher BMI values than UCP3-55T carriers (16.6 +/- 2.3 kg/m(2) vs. 16.1 +/- 1.9 kg/m(2), P = 0.016). Low physical activity may aggravate the susceptibility to overweight in UCP2-866GG and UCP3-55CC carriers.
为了研究解偶联蛋白（UCP）2和UCP3基因变异与超重及相关特征之间的关联，我们对737名韩国儿童和732名成年人的UCP2 - 866G>A、UCP2 Ala55Val和UCP3 - 55C>T进行了基因分型，并收集了人体测量状况和血液生化数据。收集了有关儿童生活方式和饮食习惯的信息。UCP2 - 866G>A和UCP3 - 55C>T基因变异在儿童中与体重指数（BMI）水平、腰围和体重显著相关，但在成年人中则不然。与 - 866GG携带者相比， - 866GA和AA携带者超重风险呈强烈下降趋势（优势比（OR），0.67；95%置信区间（CI），0.45 - 1.01；P = 0.053）。与UCP3 - 55CC携带者相比，携带 - 55CT和TT的儿童超重风险显著降低（OR，0.67；95% CI，0.46 - 0.98；P = 0.039）。也有证据表明UCP2 - UCP3联合基因型的效应与肥胖相关代谢特征之间存在相互作用。与同时携带UCP2 - 866GG和UCP3 - 55CC的人相比，联合基因型为非UCP2 - 866GG和非UCP3 - 55CC的人对超重的保护作用最大（OR，0.60；95% CI，0.38 - 0.95；P = 0.030）。在身体活动水平较低的亚组中，UCP3 - 55CC携带者的BMI值高于UCP3 - 55T携带者（16.6±2.3kg/m²对16.1±1.9kg/m²，P = 0.016）。低身体活动可能会加重UCP2 - 866GG和UCP3 - 55CC携带者超重的易感性。
