Department of Endocrinology, The First Affiliated Hospital of Nanjing Medical University, 300 Guangzhou Road, Nanjing, 210029 Jiangsu, China.
Diabetologia. 2011 Sep;54(9):2315-24. doi: 10.1007/s00125-011-2245-y. Epub 2011 Jul 13.
AIMS/HYPOTHESIS: A meta-analysis was performed to assess the association between the UCP2 -866G/A, UCP2 Ala55Val and UCP3 -55C/T polymorphisms and type 2 diabetes susceptibility.
A literature-based search was conducted to identify all relevant studies. The fixed or random effect pooled measure was calculated mainly at the allele level to determine heterogeneity bias among studies. Further analyses were performed that stratified for ethnicity.
We examined 17 publications. Stratified analysis for ethnicity and sensitivity analysis revealed that there was no heterogeneity between studies for these variants. Using an additive model, no significant association of the UCP2 -866G/A polymorphism with type 2 diabetes risk was observed, either in participants of Asian (OR 1.05, 95% CI 0.96, 1.16) or of European (OR 1.03, 95% CI 0.99, 1.07) descent. Neither the UCP2 Ala55Val nor the UCP3 -55C/T polymorphism showed any significant association with type 2 diabetes risk in Europeans (OR 1.04, 95% CI 0.98, 1.09 for Ala55Val; OR 1.04, 95% CI 1.00, 1.09 for -55C/T). In contrast, a statistically significant association was observed for both polymorphisms in participants of Asian descent (OR 1.23, 95% CI 1.12, 1.36 for Ala55Val; OR 1.15, 95% CI 1.03, 1.28 for -55C/T).
CONCLUSIONS/INTERPRETATION: Our meta-analysis suggests that the UCP2 -866G/A polymorphism is unlikely to be associated with increased type 2 diabetes risk in the populations investigated. In contrast, our results indicate that the UCP2 Ala55Val and UCP3 -55C/T polymorphisms may indeed be risk factors for susceptibility to type 2 diabetes in individuals of Asian descent, but not in individuals of European descent. This conclusion warrants confirmation by further studies.
目的/假设：进行了一项荟萃分析，以评估 UCP2-866G/A、UCP2Ala55Val 和 UCP3-55C/T 多态性与 2 型糖尿病易感性之间的关联。
进行了基于文献的搜索，以确定所有相关研究。主要在等位基因水平上计算固定或随机效应合并度量，以确定研究之间的异质性偏倚。进一步的分析按种族进行分层。
我们检查了 17 篇出版物。按种族进行分层分析和敏感性分析表明，这些变体之间的研究没有异质性。使用加性模型，UCP2-866G/A 多态性与 2 型糖尿病风险之间没有显著关联，无论是亚洲血统（OR 1.05，95%CI 0.96，1.16）还是欧洲血统（OR 1.03，95%CI 0.99，1.07）。UCP2Ala55Val 或 UCP3-55C/T 多态性在欧洲人中也与 2 型糖尿病风险无任何显著关联（OR 1.04，95%CI 0.98，1.09 用于 Ala55Val；OR 1.04，95%CI 1.00，1.09 用于-55C/T）。相比之下，这两种多态性在亚洲血统的参与者中均显示出统计学上的显著关联（OR 1.23，95%CI 1.12，1.36 用于 Ala55Val；OR 1.15，95%CI 1.03，1.28 用于-55C/T）。
结论/解释：我们的荟萃分析表明，UCP2-866G/A 多态性不太可能与所研究人群中 2 型糖尿病风险增加相关。相反，我们的结果表明，UCP2Ala55Val 和 UCP3-55C/T 多态性可能确实是亚洲血统个体 2 型糖尿病易感性的危险因素，但不是欧洲血统个体的危险因素。这一结论需要进一步的研究来证实。
