Department of Microbiology, GZA St Vincentius Hospital, St Vincentiusstraat 20, 2018 Antwerp, Belgium.
Int J Antimicrob Agents. 2011 Jan;37(1):75-7. doi: 10.1016/j.ijantimicag.2010.09.004. Epub 2010 Nov 11.
Compared with intermittent infusion, continuous infusion of vancomycin is cheaper and logistically more convenient, achieves target concentrations faster, results in less variability in serum vancomycin concentrations, requires less therapeutic drug monitoring and causes less nephrotoxicity. Given that critically ill patients may develop very large volumes of distribution as well as supranormal drug clearance, in this study it was shown, despite the limited number of patients studied, that to achieve a target plateau concentration of 25mg/L a daily dose of 3000 mg of vancomycin in continuous infusion is needed following an appropriate loading dose.
与间歇性输注相比，万古霉素连续输注更便宜，在物流方面更方便，能更快地达到目标浓度，使血清万古霉素浓度的变化更小，需要的治疗药物监测更少，且肾毒性更小。鉴于重症患者可能会出现非常大的分布容积和超正常的药物清除率，在这项研究中，尽管研究患者数量有限，但结果表明，要达到 25mg/L 的目标平台浓度，在适当的负荷剂量后，需要持续输注 3000mg 的万古霉素。
