Department of Behavioral Neurology and Cognitive Neuroscience, Tohoku University Graduate School of Medicine, 2-1 Seiryo-machi, Aoba-ku, Sendai 980-8575, Japan.
Neurosci Res. 2011 Feb;69(2):121-8. doi: 10.1016/j.neures.2010.11.001. Epub 2010 Nov 11.
We used functional magnetic resonance imaging (fMRI) to investigate the neural correlates of deception while remembering neutral events and emotional events. Before fMRI, subjects were presented with a series of neutral and emotional pictures and were asked to rate each picture for arousal. During fMRI, subjects were presented with the studied and nonstudied pictures and were asked to make an honest recognition judgment in response to half of the pictures and a dishonest response to the remaining half. We found that deception pertaining to the memory of neutral pictures was associated with increased activity in the bilateral dorsolateral prefrontal cortex, the left ventrolateral prefrontal cortex, and the left orbitofrontal cortex. We also found that deception while remembering emotional pictures was associated with increased activity in the bilateral dorsolateral prefrontal cortex. An overlapping activation between the two types of deception was found in the bilateral dorsolateral prefrontal cortex. Our results indicate that the dorsolateral prefrontal cortex is associated with the executive aspects of deception, regardless of the emotional valence of memory content.
我们使用功能磁共振成像（fMRI）来研究在回忆中性事件和情绪事件时欺骗的神经相关性。在 fMRI 之前，受试者会观看一系列中性和情绪图片，并被要求对每张图片的唤醒程度进行评分。在 fMRI 期间，受试者会观看已学习和未学习的图片，并被要求对一半的图片做出诚实的识别判断，对另一半图片做出不诚实的反应。我们发现，与中性图片记忆相关的欺骗与双侧背外侧前额叶皮层、左侧腹外侧前额叶皮层和左侧眶额皮层的活动增加有关。我们还发现，在回忆情绪图片时的欺骗与双侧背外侧前额叶皮层的活动增加有关。在两种类型的欺骗之间发现了双侧背外侧前额叶皮层的重叠激活。我们的结果表明，背外侧前额叶皮层与欺骗的执行方面有关，而与记忆内容的情绪效价无关。
