Luber Bruce, Beynel Lysianne, Spellman Timothy, Gura Hannah, Ploesser Markus, Termini Kate, Lisanby Sarah H
Noninvasive Neuromodulation Unit, Experimental Therapeutics and Pathophysiology Branch, National Institute of Mental Health, Bethesda, MD, United States.
Department of Neuroscience, University of Connecticut School of Medicine, Farmington, CT, United States.
Front Hum Neurosci. 2022 Jun 20;16:883337. doi: 10.3389/fnhum.2022.883337. eCollection 2022.
Transcranial magnetic stimulation (TMS) was used to test the functional role of parietal and prefrontal cortical regions activated during a playing card Guilty Knowledge Task (GKT). Single-pulse TMS was applied to 15 healthy volunteers at each of three target sites: left and right dorsolateral prefrontal cortex and midline parietal cortex. TMS pulses were applied at each of five latencies (from 0 to 480 ms) after the onset of a card stimulus. TMS applied to the parietal cortex exerted a latency-specific increase in inverse efficiency score and in reaction time when subjects were instructed to lie relative to when asked to respond with the truth, and this effect was specific to when TMS was applied at 240 ms after stimulus onset. No effects of TMS were detected at left or right DLPFC sites. This manipulation with TMS of performance in a deception task appears to support a critical role for the parietal cortex in intentional false responding, particularly in stimulus selection processes needed to execute a deceptive response in the context of a GKT. However, this interpretation is only preliminary, as further experiments are needed to compare performance within and outside of a deceptive context to clarify the effects of deceptive intent.
经颅磁刺激（TMS）被用于测试在扑克牌有罪知识测试（GKT）过程中激活的顶叶和前额叶皮质区域的功能作用。对15名健康志愿者的三个目标部位分别施加单脉冲TMS：左侧和右侧背外侧前额叶皮质以及中线顶叶皮质。在纸牌刺激开始后的五个时间点（从0到480毫秒）分别施加TMS脉冲。当受试者被指示说谎时，相对于被要求如实回答时，施加于顶叶皮质的TMS在特定潜伏期会使反向效率得分和反应时间增加，且这种效应在刺激开始后240毫秒施加TMS时最为明显。在左侧或右侧背外侧前额叶皮质部位未检测到TMS的影响。这种对欺骗任务中表现进行TMS操纵的结果似乎支持顶叶皮质在故意虚假反应中起关键作用，尤其是在GKT情境下执行欺骗性反应所需的刺激选择过程中。然而，这一解释只是初步的，因为需要进一步实验来比较欺骗情境内外的表现，以阐明欺骗意图的影响。
