Center for Stem Cell and Development Biology, Department of Biochemistry and Molecular Biology, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA.
Prog Mol Biol Transl Sci. 2010;97:201-27. doi: 10.1016/B978-0-12-385233-5.00007-6.
The remarkable capacity of the liver to regenerate after severe injury or disease has excited interest for centuries. The goal of harnessing this process in treatment of liver disease, and the appreciation of the parallels between regeneration and tumor development in the liver, remain a major driver for research in this area. Studies of liver regeneration as a model system offer a view of intricate and precisely timed regulatory pathways that drive the process toward completion. Successful regeneration of the liver mass demands a hierarchal and well-controlled balance between proliferative and metabolic functions, which is orchestrated by signaling and regulation of transcription factors. Control and regulation of these cascades of transcriptional activities, necessary for induction, renewal, and cessation of liver growth, are the focus of this chapter.
肝脏在严重损伤或疾病后具有很强的再生能力，这一现象引起了人们几个世纪以来的兴趣。利用这一过程来治疗肝病，并认识到肝脏再生和肿瘤发展之间的相似性，仍然是该领域研究的主要驱动力。将肝脏再生作为模型系统的研究提供了一个观察复杂而精确的调控途径的视角，这些途径推动着这一过程的完成。肝脏质量的成功再生需要在增殖和代谢功能之间建立一种层次分明且良好控制的平衡，这是由信号转导和转录因子的调控来实现的。本章的重点是对这些转录活性级联的控制和调节，这些级联对于诱导、更新和停止肝脏生长是必要的。
