Kalarickal Phillip L, Fox Charles J, Tsai Jeffrey Y, Liu Henry, Kaye Alan D
Department of Anesthesiology, Tulane University Medical Center, 1430 Tulane Avenue, SL-4, New Orleans, LA 70112, USA.
Anesthesiol Clin. 2010 Dec;28(4):739-51. doi: 10.1016/j.anclin.2010.08.007.
HMG CoA reductase inhibitors (statins) are a proven modality to reduce serum cholesterol and have been shown to reduce morbidity and mortality in cardiovascular patients. Statins have also demonstrated improvements in postoperative outcomes among patients taking them in the perioperative period. Many of the studies are limited to select patient populations and/or select surgeries. This review will give an overview of the pharmacology of statins, summarize the mechanisms of the beneficial effects of statins, and provide an overview of evidence in the use of statins in the perioperative period.
3-羟基-3-甲基戊二酰辅酶A还原酶抑制剂（他汀类药物）是一种经证实可降低血清胆固醇的药物，已被证明可降低心血管疾病患者的发病率和死亡率。他汀类药物还显示，在围手术期服用这些药物的患者术后结果有所改善。许多研究仅限于特定患者群体和/或特定手术。本综述将概述他汀类药物的药理学，总结他汀类药物有益作用的机制，并概述围手术期使用他汀类药物的证据。
