大肠杆菌 O148 脂多糖核心区域的结构及其与 O 特异性多糖的连接。
The structure of the Escherichia coli O148 lipopolysaccharide core region and its linkage to the O-specific polysaccharide.
机构信息
National Institute of Child Health and Human Development, National Institutes of Health, 9000 Rockville Pike, Bethesda, MD 20892, USA.
出版信息
Carbohydr Res. 2011 Jan 3;346(1):150-2. doi: 10.1016/j.carres.2010.10.012. Epub 2010 Oct 20.
Abstract
Recently it was demonstrated that Shigella dysenteriae type 1, a cause of severe dysentery epidemics, gained its O-specific polysaccharide (O-SP) from Escherichia coli O148. The O-SPs of these bacteria differ only by a galactose residue in the repeat unit of S. dysenteriae type 1 in place of a glucose residue in E. coli O148. Herein, we analyzed the core structure and its linkage to the O-SP in E. coli O148 LPS. Both were found to be identical to those of S. dysenteriae type 1 structures, further supporting the relatedness of these two bacteria. The following structure of the core with one repeat unit of the O-SP has been assigned (all have d-configuration except l-Rha):
摘要
最近的研究表明，志贺氏痢疾杆菌 1 型（引起严重痢疾流行的病原体）获得了其 O 特异性多糖（O-SP），来自大肠杆菌 O148。这些细菌的 O-SP 仅在重复单元中存在差异，志贺氏痢疾杆菌 1 型中的半乳糖残基取代了大肠杆菌 O148 中的葡萄糖残基。在这里，我们分析了大肠杆菌 O148 LPS 中的核心结构及其与 O-SP 的连接。结果发现，两者均与志贺氏痢疾杆菌 1 型结构相同，进一步支持了这两种细菌的亲缘关系。已指定核心结构及其 O-SP 的一个重复单元的以下结构（除 l-Rha 外均为 d-构型）：
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