Centre for Medical Parasitology, Department of International Health, Immunology and Microbiology, University of Copenhagen, Denmark.
Vaccine. 2011 Jan 10;29(3):437-43. doi: 10.1016/j.vaccine.2010.10.080. Epub 2010 Nov 12.
Malaria during pregnancy is a major cause of intra-uterine growth-retardation and infant death in sub-Saharan Africa. Ideally, this could be prevented by a vaccine delivered before the first pregnancy. Antibodies against domain DBL4ɛ from VAR2CSA has been shown to inhibit adhesion of laboratory isolates to the placental receptor chondroitin sulfate A. In this study, the binding inhibitory efficacy of IgG elicited by two different DBL4ɛ recombinant proteins was tested on a panel of fresh clinical isolates from pregnant women living in Benin and Tanzania. The most promising recombinant protein elicited antibodies with similar efficacy as pooled plasma from immune multi-gravid African women.
怀孕期间疟疾是撒哈拉以南非洲宫内生长迟缓和婴儿死亡的主要原因。理想情况下，这可以通过在第一次怀孕前接种疫苗来预防。针对 VAR2CSA 上的 DBL4ɛ 结构域的抗体已被证明可抑制实验室分离株与胎盘受体硫酸软骨素 A 的黏附。在这项研究中，对来自贝宁和坦桑尼亚的孕妇新鲜临床分离株进行了两种不同 DBL4ɛ 重组蛋白诱导的 IgG 的结合抑制效力测试。最有前途的重组蛋白所诱导的抗体与来自免疫性多胎非洲女性的血浆混合物具有相似的效力。
