College of Pharmacy, Nanjing University of Chinese Medicine, Nanjing, PR China.
Fitoterapia. 2011 Apr;82(3):375-82. doi: 10.1016/j.fitote.2010.11.012. Epub 2010 Nov 12.
Shuang-Huang-Lian (SHL), a traditional Chinese formula containing Lonicerae japonicae flos (LJF), Scutellariae radix (SR) and Forsythiae fructus (FF), is commonly used to treat acute upper respiratory tract infection, acute bronchitis and light pneumonia. Forsythoside A is one of the main active ingredients in Forsythiae fructus, a key herb in SHL. In the present study, effects of different compositions in SHL on the intestinal absorption of forsythoside A were investigated. The observations from in situ intestinal circulation model showed that A/%(h(-1)) of forsythoside A in FF+LSF, FF+SR and SHL were all reduced greatly compared with that in FF. However, in pharmacokinetics study, C(max) and AUC(0→1440) of forsythoside A all increased and T(1/2) prolonged in SHL, FF+LJF and FF+SR compared with FF. The results indicated that the different compositions of SHL decreased absorption but increased bioavailability of forsythoside A, which may be related to its metabolism inhibited in intestine or liver.
双黄连（SHL）是一种中药方剂，由金银花（LJF）、黄芩（SR）和连翘（FF）组成，常用于治疗急性上呼吸道感染、急性支气管炎和轻症肺炎。连翘酯苷 A 是连翘中的主要活性成分之一，也是 SHL 的关键药材。本研究考察了 SHL 中的不同成分对连翘酯苷 A 肠吸收的影响。在原位肠循环模型中的观察结果表明，FF+LSF、FF+SR 和 SHL 中的 A/%(h(-1))与 FF 相比均显著降低。然而，在药代动力学研究中，与 FF 相比，SHL、FF+LJF 和 FF+SR 中的连翘酯苷 A 的 C(max)和 AUC(0→1440)均增加，T(1/2)延长。结果表明，SHL 中的不同成分降低了连翘酯苷 A 的吸收，但增加了其生物利用度，这可能与肠道或肝脏中其代谢受到抑制有关。
