Pharmaceutical Sciences Laboratory, Department of Biosciences, Åbo Akademi University, BioCity, Artillerigatan 6, 20520 Turku, Finland.
Int J Pharm. 2011 Sep 30;417(1-2):227-34. doi: 10.1016/j.ijpharm.2010.11.007. Epub 2010 Nov 12.
The aim of this paper is to give an insight into photometric particle sizing approaches, which differ from the typical particle size measurement of dispersed particles. These approaches can often be advantageous especially for samples that are moist or cohesive, when dispersion of particles is difficult or sometimes impossible. The main focus of this paper is in the use of photometric stereo imaging. The technique allows the reconstruction of three-dimensional images of objects using multiple light sources in illumination. The use of photometric techniques is demonstrated in at-line measurement of granules and on-line measurement during granulation and dry milling. Also, surface visualization and roughness measurements are briefly discussed.
本文旨在深入探讨光度粒子尺寸测量方法，该方法与分散粒子的典型粒径测量方法不同。这些方法通常具有优势，尤其是在样品潮湿或粘性较大、颗粒难以分散或有时甚至无法分散的情况下。本文的主要重点是使用光度立体成像技术。该技术可使用多个光源照明来重建物体的三维图像。光度技术的应用在颗粒的在线测量以及造粒和干法粉碎过程中的在线测量中得到了展示。此外，还简要讨论了表面可视化和粗糙度测量。
