Department of Pharmacy, Faculty of Medicine, University of Tartu, Nooruse 1, 50411, Tartu, Estonia.
AAPS PharmSciTech. 2013 Sep;14(3):1129-36. doi: 10.1208/s12249-013-0002-x. Epub 2013 Jul 19.
Tablet compression of softwood cellulose and lignin prepared by a new catalytic oxidation and acid precipitation method were investigated and compared with the established pharmaceutical direct compression excipients. Catalytic pretreated softwood cellulose (CPSC) and lignin (CPSL) were isolated from pine wood (Pinus sylvestris). The compaction studies were carried out with an instrumented eccentric tablet machine. The plasticity and elasticity of the materials under compression were evaluated using force-displacement treatment and by determining characteristic plasticity (PF) and elasticity (EF) factors. With all biomaterials studied, the PF under compression decreased exponentially as the compression force increased. The compression force applied in tablet compression did not significantly affect the elasticity of CPSC and microcrystalline cellulose (MCC) while the EF values for softwood lignins increased as compression force increased. CPSL was clearly a less plastically deforming and less compactable material than the two celluloses (CPSC and MCC) and hardwood lignin. CPSL presented deformation and compaction behaviour almost identical to that of lactose monohydrate. In conclusion, the direct tablet compression behaviour of native lignins and celluloses can greatly differ from each other depending on the source and isolation method used.
采用新的催化氧化和酸沉淀方法制备的软木纤维素和木质素的片剂压缩性能进行了研究，并与已建立的医药直接压片辅料进行了比较。催化预处理的软木纤维素（CPSC）和木质素（CPSL）是从松木（Pinus sylvestris）中分离出来的。使用仪器偏心压片机进行压缩研究。通过力-位移处理和确定特征塑性（PF）和弹性（EF）因子来评估材料在压缩下的塑性和弹性。在所研究的所有生物材料中，随着压缩力的增加，PF 在压缩下呈指数下降。在片剂压缩中施加的压缩力对 CPSC 和微晶纤维素（MCC）的弹性没有显著影响，而软木木质素的 EF 值随着压缩力的增加而增加。CPSL 显然比两种纤维素（CPSC 和 MCC）和硬木木质素的变形能力和可压缩性差。CPSL 的变形和压缩行为几乎与一水乳糖相同。总之，根据所用的来源和分离方法，天然木质素和纤维素的直接片剂压缩性能可能有很大差异。
