Macari M, Pela I R, Silva C A, Viana R S
Departamento de Morfologia e Fisiologia Animal, Faculdade de Ciencias Agrarias e Veterinarias de Jaboticabal, SP, Brasil.
Pflugers Arch. 1990 Jan;415(4):440-3. doi: 10.1007/BF00373621.
The development of a fever in response to intravenous (IV, 1.5 micrograms/kg body mass) and intracerebroventricular (ICV, 1.5 micrograms/animal) injections of Escherichia coli lipopolysaccharide (LPS) was studied in control, thyroidectomised and protein-calorie malnourished rabbits (New Zealand Whites, n = 55). ICV injection of LPS in control rabbits produced a fever response, the characteristics of which differed from those obtained after IV pyrogen injection. Thyroid deficiency caused an attenuated fever response, irrespective of whether LPS had been administered by IV or ICV injection. Protein-calorie malnourished rabbits showed a smaller fever response after IV or ICV pyrogen injections. Malnourished rabbits, refed over a period of 15 days, showed a typical biphasic fever response, but with lower magnitude than controls. The results of these experiments suggest that ICV injection of LPS is not an appropriate model for the study of fever mechanisms in disease states, and that the attenuated fever response observed in protein-calorie malnourished rabbits may be related, at least in part, to a decreased ability to produce the endogenous pyrogen interleukin-1.
在对照、甲状腺切除及蛋白质 - 热量营养不良的家兔（新西兰白兔，n = 55）中，研究了静脉注射（IV，1.5微克/千克体重）和脑室内注射（ICV，1.5微克/只动物）大肠杆菌脂多糖（LPS）后发热的情况。在对照家兔中，脑室内注射LPS会产生发热反应，其特征与静脉注射热原后的反应不同。甲状腺功能减退导致发热反应减弱，无论LPS是通过静脉注射还是脑室内注射给药。蛋白质 - 热量营养不良的家兔在静脉或脑室内注射热原后发热反应较小。营养不良的家兔在15天的再喂养期间表现出典型的双相发热反应，但程度低于对照组。这些实验结果表明，脑室内注射LPS不是研究疾病状态下发热机制的合适模型，并且在蛋白质 - 热量营养不良的家兔中观察到的发热反应减弱可能至少部分与产生内源性热原白细胞介素 - 1的能力降低有关。
