Stitt J T, Bernheim H A
J Appl Physiol (1985). 1985 Aug;59(2):342-7. doi: 10.1152/jappl.1985.59.2.342.
We have compared the characteristics of fevers produced by endogenous pyrogen administered by the intravenous (iv) and by the intracerebroventricular (icv) routes in conscious rabbits. Fevers induced by the intracerebroventricular route have a longer latency to onset, a less steep rise in body temperature, and a longer time to peak elevation in body temperature than do fevers induced by the intravenous route. Furthermore, a dose of indomethacin (2 mg/kg) administered intravenously, which is effective in markedly attenuating fevers produced by the intravenous route, was completely without effect on fevers induced by the intracerebroventricular route. On the other hand, when indomethacin (500 micrograms) was infused intracerebroventricularly, it markedly reduced fevers induced by the subsequent injection of endogenous pyrogen into the contralateral cerebral ventricle, but such pretreatment had little effect on fevers elicited by intravenous injections of endogenous pyrogen. It is concluded that the sites of action of endogenous pyrogen in response to intravenous injections of pyrogen are different from those responding to intracerebroventricular injections of pyrogen and that this is manifest in several distinct differences in the characteristics of the two fevers. These results indicate that the intracerebroventricular model of fever production is not appropriate for the study of the normal pathogenesis of fever.
我们比较了清醒家兔经静脉（iv）和脑室内（icv）途径注射内源性致热原所产生发热的特点。与静脉途径诱导的发热相比，脑室内途径诱导的发热起效潜伏期更长，体温上升不那么陡峭，体温达到峰值升高的时间更长。此外，静脉注射一剂吲哚美辛（2mg/kg），可有效显著减轻静脉途径产生的发热，但对脑室内途径诱导的发热完全没有作用。另一方面，当脑室内注入吲哚美辛（500微克）时，它能显著降低随后向对侧脑室注射内源性致热原所诱导的发热，但这种预处理对静脉注射内源性致热原引起的发热几乎没有影响。结论是，静脉注射致热原时内源性致热原的作用部位与脑室内注射致热原时的作用部位不同，这在两种发热的特征上表现为几个明显的差异。这些结果表明，发热产生的脑室内模型不适用于研究发热的正常发病机制。
