Kozak W, Soszynski D, Szewczenko M, Bodurka M
Department of Physiology, Medical University of Bydgoszcz, Poland.
Experientia. 1990 Oct 15;46(10):1010-1. doi: 10.1007/BF01940657.
Successive injections of lipopolysaccharide (LPS) either intravenously (i.v.) or intracerebroventricularly (i.c.v.) induced pyrogenic tolerance to LPS in rabbits. Tolerance was shown by a decrease of the magnitude of the fever response to repeated doses of LPS, irrespective of the route of pyrogen administration. A significantly greater and more dramatic decrease of the fever index, however, was observed in rabbits made tolerant to pyrogen given i.v. than when the pyrogen was given i.c.v. Transmission of the pyrogenic tolerance between brain and peripheral tissues, however, has not been ascertained.
静脉内（i.v.）或脑室内（i.c.v.）连续注射脂多糖（LPS）可诱导家兔对LPS产生热原耐受性。无论热原给药途径如何，对重复剂量LPS的发热反应幅度降低表明出现了耐受性。然而，静脉内给予热原的家兔比脑室内给予热原的家兔发热指数的降低更为显著和明显。然而，热原耐受性在脑和外周组织之间的传递尚未得到证实。
