Department of Neurology, Medical Division, Akershus University Hospital, Lørenskog, Norway.
J Stroke Cerebrovasc Dis. 2012 Jul;21(5):369-72. doi: 10.1016/j.jstrokecerebrovasdis.2010.09.012. Epub 2010 Nov 13.
In this study, we investigated predictors for long-term all-cause mortality in a cohort of patients hospitalized for acute stroke. We prospectively followed 550 patients aged ≥ 60 years who were consecutively admitted within 24 hours of sustaining acute stroke. The patients were followed for 12 years or until death, whichever came first. Multivariate Cox regression models were used to analyze predictors of all-cause mortality, with the following independent variables: age, sex, living alone, previous stroke, ischemic heart disease, atrial fibrillation, hypertension, diabetes, cancer, current smoker, hemorrhagic stroke, treatment in an acute stroke unit, and stroke severity (measured with the Scandinavian Stroke Scale). The 12-year mortality rate was 86.5%. In a multivariate model, all-cause mortality was associated with the following variables: age (hazard ratio, 1.08; 95% confidence interval, 1.07-1.10), male sex (1.69, 1.40-2.05), previous stroke (1.34, 1.08-1.65), ischemic heart disease (1.30, 1.02-1.64), diabetes (1.74, 1.36-2.23), hemorrhagic stroke (1.58, 1.20-2.08), and stroke severity (1.03, 1.03-1.04); Age, male sex, stroke severity, ischemic heart disease, diabetes, and hemorrhagic stroke were all independently associated with an increased risk of all-cause mortality over the 12-year period after stroke.
在这项研究中，我们调查了急性中风住院患者队列中与长期全因死亡率相关的预测因素。我们前瞻性地随访了 550 名年龄≥60 岁的患者，这些患者在急性中风发生后 24 小时内连续入院。这些患者被随访了 12 年或直到死亡，以先发生者为准。我们使用多变量 Cox 回归模型来分析全因死亡率的预测因素，独立变量包括：年龄、性别、独居、既往中风、缺血性心脏病、心房颤动、高血压、糖尿病、癌症、当前吸烟者、出血性中风、急性中风单元治疗和中风严重程度（用斯堪的纳维亚中风量表测量）。12 年死亡率为 86.5%。在多变量模型中，全因死亡率与以下变量相关：年龄（风险比，1.08；95%置信区间，1.07-1.10）、男性（1.69，1.40-2.05）、既往中风（1.34，1.08-1.65）、缺血性心脏病（1.30，1.02-1.64）、糖尿病（1.74，1.36-2.23）、出血性中风（1.58，1.20-2.08）和中风严重程度（1.03，1.03-1.04）；年龄、男性、中风严重程度、缺血性心脏病、糖尿病和出血性中风均与中风后 12 年内全因死亡率增加独立相关。
