Department of Microbiology, Tumor and Cell Biology, Karolinska Institute, Stockholm, Sweden.
J Bacteriol. 2011 Jan;193(2):580-2. doi: 10.1128/JB.00905-10. Epub 2010 Nov 12.
CsgD and cyclic-3',5'-di-guanylate are key regulators of biofilm formation in Salmonella enterica serovar Typhimurium. Our results show that polynucleotide phosphorylase and NlpI oppositely altered expression of CsgD. Polynucleotide phosphorylase and NlpI also had opposite effects on the expression of yjcC, which codes for a cyclic-3',5'-di-guanylate phosphodiesterase affecting CsgD expression.
CsgD 和环-3',5'-二鸟苷酸是肠炎沙门氏菌生物膜形成的关键调节剂。我们的结果表明,多核苷酸磷酸化酶和 NlpI 改变了 CsgD 的表达。多核苷酸磷酸化酶和 NlpI 对编码影响 CsgD 表达的环-3',5'-二鸟苷酸磷酸二酯酶的 yjcC 的表达也有相反的影响。