端粒蛋白端粒酶1调节端粒处的DNA损伤反应。
The telomere protein tankyrase 1 regulates DNA damage responses at telomeres.
作者信息
Chang Sandy
出版信息
Aging (Albany NY). 2010 Oct;2(10):639-42. doi: 10.18632/aging.100221.
Abstract
The proliferative potential of eukaryotic cells is critically dependent upon the maintenance of functional telomeres, the protein-DNA complexes that cap the ends of chromosomes. A paper published in this issue of Aging describes that the telomere protein tankyrase 1 regulates DNA damage responses at telomeres.
摘要
真核细胞的增殖潜能严重依赖于功能性端粒的维持，端粒是覆盖染色体末端的蛋白质 - DNA 复合物。发表在本期《衰老》杂志上的一篇论文描述了端粒蛋白端粒酶 1 调节端粒处的 DNA 损伤反应。
相似文献
1
The telomere protein tankyrase 1 regulates DNA damage responses at telomeres.
Aging (Albany NY). 2010 Oct;2(10):639-42. doi: 10.18632/aging.100221.
2
Regulatory roles of tankyrase 1 at telomeres and in DNA repair: suppression of T-SCE and stabilization of DNA-PKcs.
Aging (Albany NY). 2010 Oct;2(10):691-708. doi: 10.18632/aging.100210.
3
Role for the related poly(ADP-Ribose) polymerases tankyrase 1 and 2 at human telomeres.
Mol Cell Biol. 2002 Jan;22(1):332-42. doi: 10.1128/MCB.22.1.332-342.2002.
4
Telomere sister chromatid exchange and the process of aging.
Aging (Albany NY). 2010 Oct;2(10):727-30. doi: 10.18632/aging.100206.
5
DNA-dependent protein kinase modulates the anti-cancer properties of silver nanoparticles in human cancer cells.
Mutat Res Genet Toxicol Environ Mutagen. 2017 Dec;824:32-41. doi: 10.1016/j.mrgentox.2017.10.001. Epub 2017 Oct 13.
6
Ku70 stimulates fusion of dysfunctional telomeres yet protects chromosome ends from homologous recombination.
Nat Cell Biol. 2006 Aug;8(8):885-90. doi: 10.1038/ncb1444. Epub 2006 Jul 16.
7
Functions of ADP-ribose transferases in the maintenance of telomere integrity.
Cell Mol Life Sci. 2022 Mar 29;79(4):215. doi: 10.1007/s00018-022-04235-z.
8
Tankyrase function at telomeres, spindle poles, and beyond.
Biochimie. 2008 Jan;90(1):83-92. doi: 10.1016/j.biochi.2007.07.012. Epub 2007 Jul 24.
9
The role of recombination in telomere length maintenance.
Biochem Soc Trans. 2009 Jun;37(Pt 3):589-95. doi: 10.1042/BST0370589.
10
Cell cycle-regulated ubiquitination of tankyrase 1 by RNF8 and ABRO1/BRCC36 controls the timing of sister telomere resolution.
EMBO J. 2017 Feb 15;36(4):503-519. doi: 10.15252/embj.201695135. Epub 2016 Dec 19.
引用本文的文献
1
Analysis of Genes Involved in Body Weight Regulation by Targeted Re-Sequencing.
PLoS One. 2016 Feb 1;11(2):e0147904. doi: 10.1371/journal.pone.0147904. eCollection 2016.
2
Controversial aspects of oncogene-induced senescence.
Cell Cycle. 2012 Nov 15;11(22):4147-51. doi: 10.4161/cc.22589. Epub 2012 Oct 24.
3
Shelterin complex and associated factors at human telomeres.
Nucleus. 2011 Mar-Apr;2(2):119-35. doi: 10.4161/nucl.2.2.15135.
4
Induction and persistence of radiation-induced DNA damage is more pronounced in young animals than in old animals.
Aging (Albany NY). 2011 Jun;3(6):609-20. doi: 10.18632/aging.100340.
本文引用的文献
1
Regulatory roles of tankyrase 1 at telomeres and in DNA repair: suppression of T-SCE and stabilization of DNA-PKcs.
Aging (Albany NY). 2010 Oct;2(10):691-708. doi: 10.18632/aging.100210.
2
Hyper telomere recombination accelerates replicative senescence and may promote premature aging.
Proc Natl Acad Sci U S A. 2010 Sep 7;107(36):15768-73. doi: 10.1073/pnas.1006338107. Epub 2010 Aug 23.
3
The function of classical and alternative non-homologous end-joining pathways in the fusion of dysfunctional telomeres.
EMBO J. 2010 Aug 4;29(15):2598-610. doi: 10.1038/emboj.2010.142. Epub 2010 Jun 29.
4
Assaying and investigating Alternative Lengthening of Telomeres activity in human cells and cancers.
FEBS Lett. 2010 Sep 10;584(17):3800-11. doi: 10.1016/j.febslet.2010.06.009. Epub 2010 Jun 11.
5
TRF2/RAP1 and DNA-PK mediate a double protection against joining at telomeric ends.
EMBO J. 2010 May 5;29(9):1573-84. doi: 10.1038/emboj.2010.49. Epub 2010 Apr 20.
6
Alternative lengthening of telomeres: models, mechanisms and implications.
Nat Rev Genet. 2010 May;11(5):319-30. doi: 10.1038/nrg2763. Epub 2010 Mar 30.
7
The mre11 complex and the response to dysfunctional telomeres.
Mol Cell Biol. 2009 Oct;29(20):5540-51. doi: 10.1128/MCB.00479-09. Epub 2009 Aug 10.
8
Cell cycle-dependent role of MRN at dysfunctional telomeres: ATM signaling-dependent induction of nonhomologous end joining (NHEJ) in G1 and resection-mediated inhibition of NHEJ in G2.
Mol Cell Biol. 2009 Oct;29(20):5552-63. doi: 10.1128/MCB.00476-09. Epub 2009 Aug 10.
9
Multiple roles for MRE11 at uncapped telomeres.
Nature. 2009 Aug 13;460(7257):914-8. doi: 10.1038/nature08196. Epub 2009 Jul 26.
10
Inhibition of poly(ADP-ribose) polymerase in tumors from BRCA mutation carriers.
N Engl J Med. 2009 Jul 9;361(2):123-34. doi: 10.1056/NEJMoa0900212. Epub 2009 Jun 24.
Zotero 插件