Chung S I, Livingston C W, Edwards J F, Crandell R W, Shope R E, Shelton M J, Collisson E W
Department of Veterinary Microbiology and Parasitology, College of Veterinary Medicine, Texas A&M University, College Station 77843.
Vet Microbiol. 1990 Feb;21(4):297-307. doi: 10.1016/0378-1135(90)90001-c.
An outbreak of congenital abnormalities occurred in sheep at San Angelo, Texas, between December 1986 and February 1987. Of 360 lambs born, 19.2% had arthrogryposis or other musculo-skeletal problems and hydranencephaly (AGH), and the total neonatal loss was 25.6%. In 1987, all ewes that were tested with AGH lambs had antibody to Cache Valley virus (CVV), whereas 62% of the ewes with normal lambs had CVV-specific antibody. Pre-colostral serum samples from AGH lambs had neutralizing antibody to CVV. An increase in prevalence of CVV-specific antibody, from 5% during the spring of 1986 to 63.4% during the winter of 1987, occurred during a time that included the gestation of these affected lambs, as well as a period of increased rainfall. The isolation of a CVV-related strain from a sentinel sheep in October 1987 confirmed the continued presence of this virus in the pasture where this outbreak occurred and provided a recent field strain for future studies.
1986年12月至1987年2月期间，得克萨斯州圣安杰洛的绵羊中发生了先天性异常疫情。在出生的360只羔羊中，19.2%患有关节弯曲或其他肌肉骨骼问题以及积水性无脑畸形（AGH），新生儿总损失率为25.6%。1987年，所有产下AGH羔羊的母羊都有抗卡什谷病毒（CVV）的抗体，而产下正常羔羊的母羊中有62%有CVV特异性抗体。AGH羔羊的初乳前血清样本中有抗CVV的中和抗体。在包括这些受影响羔羊的妊娠期以及降雨增加的时期内，CVV特异性抗体的流行率从1986年春季的5%上升到1987年冬季的63.4%。1987年10月从一只哨兵羊中分离出一株与CVV相关的毒株，证实了该病毒在此次疫情发生的牧场中持续存在，并为未来研究提供了一株近期的野外毒株。
