子宫内接种梅因德雷病毒、圣安杰洛病毒和拉克罗斯病毒诱导的绵羊胎儿畸形。

Ovine fetal malformations induced by in utero inoculation with Main Drain, San Angelo, and LaCrosse viruses.

作者信息

Edwards J F, Karabatsos N, Collisson E W, de la Concha Bermejillo A

机构信息

Department of Veterinary Pathobiology, College of Veterinary Medicine, Texas A&M University, College Station, USA.

出版信息

Am J Trop Med Hyg. 1997 Feb;56(2):171-6. doi: 10.4269/ajtmh.1997.56.171.

DOI:10.4269/ajtmh.1997.56.171

PMID:9080876

Abstract

The teratogenic potential of three bunyaviruses, two California serogroup bunyaviruses, LaCrosse virus and San Angelo virus, and a Bunyamwera serogroup member, Main Drain virus, in sheep was studied following in utero inoculation of ewes in early gestation. Although Main Drain virus appeared to be most teratogenic, all three viruses induced a range of lesions including arthrogryposis, hydrocephalus, fetal death, axial skeletal deviations, anasarca, and oligohydramnios. The teratogenic effects of these viruses are identical to those described in ovine infections by Cache Valley and Akabane viruses. Demonstration of a common bunyaviral tropism for fetal tissue infection that results in congenital brain and musculoskeletal malformations provides evidence that human in utero infection by bunyaviruses could result in similar malformations in human infants.

摘要

在妊娠早期对母羊进行子宫内接种后，研究了三种布尼亚病毒（两种加利福尼亚血清群布尼亚病毒，即拉克罗斯病毒和圣安杰洛病毒，以及布尼亚姆韦拉血清群成员梅因德林病毒）对绵羊的致畸潜力。尽管梅因德林病毒似乎致畸性最强，但这三种病毒均引发了一系列病变，包括关节弯曲、脑积水、胎儿死亡、轴向骨骼偏差、全身性水肿和羊水过少。这些病毒的致畸作用与在绵羊感染卡奇谷病毒和赤羽病毒时所描述的作用相同。对导致先天性脑和肌肉骨骼畸形的胎儿组织感染存在共同的布尼亚病毒嗜性的证明，为布尼亚病毒在子宫内感染人类可导致人类婴儿出现类似畸形提供了证据。