Faculty of Chemistry, Wroclaw University of Technology, Wybrzeze Wyspianskiego 27, 50-370 Wroclaw, Poland.
Molecules. 2010 Nov 12;15(11):8214-28. doi: 10.3390/molecules15118214.
Various N-substituted benzisoselenazol-3(2H)-ones and their non-selenium-containing analogues have been synthesized and tested against selected viruses (HHV-1, EMCV and VSV) to determine the extent to which selenium plays a role in antiviral activity. The data presented here show that the presence of selenium is crucial for the antiviral properties of benzisoselenazol-3(2H)-ones since their isostructural analogues having different groups but lacking selenium either did not show any antiviral activity or their activity was substantially lower. The open-chain analogues of benzisoselenazol-3(2H)-ones--diselenides also exhibited high antiviral activity while selenides and disulfides were completely inactive towards model viruses.
各种 N-取代的苯并硒唑-3(2H)-酮及其不含硒的类似物已被合成并针对选定的病毒（HHV-1、EMCV 和 VSV）进行了测试，以确定硒在抗病毒活性中起到何种作用。这里呈现的数据表明，硒的存在对于苯并硒唑-3(2H)-酮的抗病毒性质至关重要，因为它们的等结构类似物具有不同的基团但不含硒，既没有显示出任何抗病毒活性，也没有显示出显著降低的抗病毒活性。苯并硒唑-3(2H)-酮的开链类似物——二硒化物也表现出了高抗病毒活性，而硒化物和二硫化物对模型病毒完全没有活性。
