Instituto de Neurociencias de Alicante, Universidad Miguel Hernández-Consejo Superior de Investigaciones Científicas, San Juan de Alicante, Spain.
Nat Med. 2010 Dec;16(12):1396-9. doi: 10.1038/nm.2264. Epub 2010 Nov 14.
Basal tearing is crucial to maintaining ocular surface wetness. Corneal cold thermoreceptors sense small oscillations in ambient temperature and change their discharge accordingly. Deletion of the cold-transducing ion channel Transient receptor potential cation channel subfamily M member 8 (TRPM8) in mice abrogates cold responsiveness and reduces basal tearing without affecting nociceptor-mediated irritative tearing. Warming of the cornea in humans also decreases tearing rate. These findings indicate that TRPM8-dependent impulse activity in corneal cold receptors contributes to regulating basal tear flow.
基础泪液分泌对于维持眼表面湿润至关重要。角膜冷感受器感知环境温度的微小波动，并相应改变其放电。在小鼠中删除冷转导离子通道瞬时受体电位阳离子通道亚家族 M 成员 8（TRPM8）会消除冷反应性，并减少基础流泪而不影响伤害感受器介导的刺激性流泪。人类角膜加温也会降低流泪率。这些发现表明，角膜冷感受器中依赖于 TRPM8 的冲动活动有助于调节基础泪液流量。
