Department of Surgery, Oncology Institute, Loyola University Medical Center Stritch School of Medicine, Maywood, IL 60153, USA.
Surg Oncol. 2012 Sep;21(3):172-7. doi: 10.1016/j.suronc.2011.09.001. Epub 2011 Oct 1.
The concept of the tumor microenvironment, developed from Paget's "seed and soil" theory is made up of the cancer cells, the stromal tissue, and the extracellular matrix. In this mini-review, each of the components of this dynamic network will be examined. We will show that there are a multitude of complex interactions and a host of molecules involved in tumorogenesis and metastasis. We will further illustrate this notion with examples from the tumor microenvironment of breast cancer. Lastly, we conclude with thoughts about how this will influence the surgical field with examples of therapeutic agents already in use that target aspects of this microenvironment.
肿瘤微环境的概念源于 Paget 的“种子与土壤”理论，由癌细胞、基质组织和细胞外基质组成。在这篇综述中，我们将逐一研究这个动态网络的各个组成部分。我们将展示在肿瘤发生和转移过程中存在着大量复杂的相互作用和分子。我们将进一步通过乳腺癌肿瘤微环境的实例来说明这一概念。最后，我们将以已经用于靶向该微环境某些方面的治疗剂为例，说明这将如何影响外科领域。
