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[New possibilities for automated diagnosis of dementia].

作者信息

Klöppel S

机构信息

Neurozentrum, Freiburg Brain Imaging, Zentrum für Geriatrie und Gerontologie, Abteilung für Psychiatrie und Psychotherapie, Universitätsklinikum Freiburg, Hauptstraße 5, 79104, Freiburg.

出版信息

Nervenarzt. 2010 Dec;81(12):1456-9. doi: 10.1007/s00115-010-3104-7.

DOI:10.1007/s00115-010-3104-7
PMID:21076807
Abstract

Dementia is underdiagnosed and undertreated in Germany. Automatic diagnosing of dementia based on standard magnetic resonance imaging has the capacity to reduce diagnostic uncertainties. The algorithm learns a disease specific pattern of atrophy from training samples. It is independent from radiological expertise which may be scarce outside specialised centres and can be installed on MRT-machines or desktop PCs. It can also play its part in planning and conducting treatment trials by recruiting a sample with predicted fast future decline. Extension, based e.g. on resting state functional imaging are possible but are further away from clinical routine.

摘要

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Altered brain activation during a verbal working memory task in subjects with amnestic mild cognitive impairment.遗忘型轻度认知障碍患者言语工作记忆任务中的大脑激活改变。
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Divergent network connectivity changes in behavioural variant frontotemporal dementia and Alzheimer's disease.
行为变异型额颞叶痴呆和阿尔茨海默病的网络连接连通性变化不同。
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