University of Iowa College of Medicine, University of Iowa Hospitals and Clinics, Iowa City, Iowa, USA.
Head Neck. 2011 May;33(5):638-44. doi: 10.1002/hed.21506. Epub 2010 Nov 12.
The purpose of this study was to examine the effect of continued oral intake and duration of gastrostomy tube placement on posttreatment nutritional outcomes in patients being irradiated for head and neck cancer.
Factors associated with continued oral intake and its association with posttreatment outcomes were analyzed.
Patients with no oral intake (39.6% of 91) were more likely to have laryngeal tumors, advanced disease, and pretreatment gastrostomy tube placement. Of the 55 patients whose gastrostomy tubes had been removed, those with continued oral intake and shorter gastrostomy tube placement were more likely to maintain their weight and report eating scores in the higher-functioning category, but have more restricted diets. Observed survival was significantly better for the continued-oral-intake group (p = .001).
The beneficial effects of continued oral intake and shorter gastrostomy tube placement on posttreatment outcomes shown in this study suggest that clinicians involved in these patients' care should emphasize oral intake during treatment.
本研究旨在探讨头颈部癌症放疗患者持续口服摄入及其胃管放置时间对治疗后营养结局的影响。
分析了与持续口服摄入相关的因素及其与治疗后结局的关系。
无口服摄入的患者（91 例中的 39.6%）更可能患有喉肿瘤、晚期疾病和治疗前胃管放置。在 55 例胃管已移除的患者中，那些继续口服摄入且胃管放置时间较短的患者更有可能保持体重，并报告在更高功能类别中进食评分，但饮食限制更多。持续口服摄入组的观察生存率显著更好（p=0.001）。
本研究表明，持续口服摄入和较短胃管放置对治疗后结局的有益影响表明，参与这些患者治疗的临床医生应在治疗期间强调口服摄入。
