Guney S, Guney N, Ozcan D, Sayilgan T, Ozakin E
Department of Urology, Sisli Etfal Research and Training Hospital, Istanbul, Turkey.
Eur J Gynaecol Oncol. 2010;31(3):339-41.
Ovarian metastases from renal cell carcinoma (RCC) are very rare, with only 23 cases reported in the literature. We report a case of 54-year-old women who developed bilateral ovarian metastasis 39 months after diagnosis of clear cell carcinoma. Total abdominal hysterectomy with bilateral salpingo-oophorectomy was carried out. Subsequently she was treated with sunitinib and her disease stabilized. She is still alive four years after diagnosis of the renal primary, and disease has stabilized on sunitinib. We conclude that, although rare, the possibility of metastatic RCC should be considered in the differential diagnosis of clear cell tumors of the ovary. Due to therapeutic and prognostic implications, it is very important to differentiate if the tumor is a primary ovarian tumor or a metastasis from a renal cell carcinoma. Early diagnosis of this rare metastatic tumor results in prompt treatment and prolonged patient survival.
肾细胞癌（RCC）的卵巢转移非常罕见，文献中仅报道过23例。我们报告一例54岁女性，在诊断为透明细胞癌39个月后发生双侧卵巢转移。实施了全腹子宫切除术及双侧输卵管卵巢切除术。随后她接受了舒尼替尼治疗，病情稳定。在诊断出原发性肾癌四年后她仍然存活，且疾病在舒尼替尼治疗下保持稳定。我们得出结论，尽管罕见，但在卵巢透明细胞肿瘤的鉴别诊断中应考虑转移性RCC的可能性。由于治疗和预后的影响，区分肿瘤是原发性卵巢肿瘤还是肾细胞癌转移非常重要。这种罕见的转移性肿瘤的早期诊断可带来及时治疗并延长患者生存期。
