Koufopoulos Nektarios, Nasi Despoina, Antoniadou Foteini, Kokkali Stefania, Theocharis Stamatios
Department of Pathology, "Saint Savvas" Cancer Hospital, Athens, GRC.
Department of Oncology, "Saint Savvas" Cancer Hospital, Athens, GRC.
Cureus. 2018 Nov 21;10(11):e3620. doi: 10.7759/cureus.3620.
Ovarian metastasis is common with secondary tumors representing up to 15% of ovarian neoplasms. The malignancies most commonly involving the ovaries are carcinomas of the stomach, colon, breast, endocervix, endometrium, and lymphoma. Secondary ovarian involvement by kidney carcinoma occurs very rarely and is usually associated with widespread dissemination. We conducted a review of kidney carcinoma with ovarian metastasis in the literature using the keywords clear cell renal cell carcinoma, papillary renal cell carcinoma, chromophobe renal cell carcinoma collecting duct carcinoma, and ovarian metastasis on Google Scholar and PubMed indices in April 2018, including a case diagnosed in our department. To date, 30 articles presenting 41 cases of kidney carcinoma with ovarian metastasis are reported in the literature. All reviewed cases were analyzed for diagnosis, surgical and systemic therapy, and outcome. Diagnosis may sometimes be challenging, requiring appropriate immunohistochemical markers in difficult cases. A combination of surgery and adjuvant therapy offers significant benefit in disease control or palliation of symptoms. Due to inconsistency in the reported data, further studies are needed to make safe conclusions regarding survival.
卵巢转移在继发性肿瘤中很常见，继发性肿瘤占卵巢肿瘤的比例高达15%。最常累及卵巢的恶性肿瘤是胃癌、结肠癌、乳腺癌、子宫颈癌、子宫内膜癌和淋巴瘤。肾癌很少发生继发性卵巢受累，通常与广泛播散有关。我们于2018年4月在谷歌学术和PubMed数据库中使用关键词“透明细胞肾细胞癌”“乳头状肾细胞癌”“嫌色性肾细胞癌”“集合管癌”和“卵巢转移”对文献中肾癌伴卵巢转移的情况进行了综述，包括我科诊断的1例病例。迄今为止，文献报道了30篇文章，共41例肾癌伴卵巢转移病例。对所有纳入综述的病例进行了诊断、手术和全身治疗以及预后分析。诊断有时具有挑战性，在疑难病例中需要合适的免疫组化标志物。手术和辅助治疗相结合在疾病控制或症状缓解方面具有显著益处。由于报告数据不一致，需要进一步研究以得出关于生存的可靠结论。
