ACS Appl Mater Interfaces. 2010 Dec;2(12):3401-5. doi: 10.1021/am100737s. Epub 2010 Nov 15.
In this study, a series of electrochemically active oligo(ethylene glycol) (OEG) linear-dendrons have been synthesized and grafted onto electrode surfaces by cyclic voltammetry (CV) to improve protein resistance. Dendronized molecules with peripheral carbazole functionality and branching architecture enabled tethering of the poly(ethylene glycol) (PEG) or OEG group with a predictable number of electrochemical reactive groups affecting OEG distribution and orientation. It is possible that ample spacing between the OEG chains affects the intrinsic hydration of these layers and thus surface protein resistance. The films were characterized by CV, surface plasmon resonance (SPR), static contact angle measurements, and atomic force microscopy (AFM). This approach should enable improved nonbiofouling properties on biorelevant electrode surfaces (metal or metal oxides) by potentiostatic or potentiodynamic electrochemical methods, providing an alternative to the self-assembled monolayer (SAM) approach for anchoring PEG layers.
在这项研究中，通过循环伏安法（CV）合成了一系列具有电化学活性的聚（乙二醇）（OEG）线性树枝状分子，并将其接枝到电极表面，以提高蛋白质抗性。具有外围咔唑官能团和分支结构的树枝状分子能够将聚（乙二醇）（PEG）或 OEG 基团与一定数量的电化学活性基团连接起来，从而影响 OEG 的分布和取向。OEG 链之间的充分间隔可能会影响这些层的固有水合作用，从而影响表面蛋白质抗性。通过 CV、表面等离子体共振（SPR）、静态接触角测量和原子力显微镜（AFM）对薄膜进行了表征。通过这种方法，通过恒电位或恒电流电化学方法，应该能够在生物相关电极表面（金属或金属氧化物）上实现更好的抗生物污染性能，为锚定 PEG 层提供了一种替代自组装单分子层（SAM）方法的选择。
