Department of Applied Life science, Kon Kuk University, Seoul, South Korea.
Immunopharmacol Immunotoxicol. 2011 Sep;33(3):450-3. doi: 10.3109/08923973.2010.532805. Epub 2010 Nov 16.
The leaves of Foeniculum vulgare (Umbelliferae) were extracted and the major essential oil composition and immunotoxicity effects were studied. The analyses conducted by gas chromatography and mass spectroscopy (GC-MS) revealed the essential oils of F. vulgare leaves. The F. vulgare essential oil yield was 0.97%, and GC/MS analysis revealed that its major constituents were methyl clavicol (46.3%), α-phellandrene (18.2%), fenchone (10.6%), (E)-anethole (11.3%), myrcene (3.4%), and α-pinene (2.1%). The essential oil had a significant toxic effect against early fourth-stage larvae of Aedes aegypti L with an LC(50) value of 41.23 ppm and an LC(90) value of 65.24 ppm. Also, methyl clavicol (≥98.0%), α-phellandrene (≥95.0%), fenchone (≥98.0%), (E)-anethole (≥99.0%), myrcene (≥99.0%), and α-pinene (≥99.0%) were tested against the F(21) laboratory strain of A. aegypti. Fenchone (≥98.0%) and (E)-anethole (≥99.0%) have medium activity with an LC(50) value of 73.11 ppm and 102.41 ppm. The above data indicate that major compounds interaction may play a more important role in the toxicity of essential oil.
对茴香（伞形科）的叶片进行了提取，并研究了其主要精油成分和免疫毒性作用。气相色谱和质谱（GC-MS）分析表明，茴香叶片的精油含有甲基丁香酚（46.3%）、α-水芹烯（18.2%）、葑酮（10.6%）、（E）-茴香脑（11.3%）、月桂烯（3.4%）和α-蒎烯（2.1%）。该精油对埃及伊蚊第四龄早期幼虫具有显著的毒性作用，LC50 值为 41.23ppm，LC90 值为 65.24ppm。此外，还对甲基丁香酚（≥98.0%）、α-水芹烯（≥95.0%）、葑酮（≥98.0%）、（E）-茴香脑（≥99.0%）、月桂烯（≥99.0%）和α-蒎烯（≥99.0%）进行了测试，结果表明，葑酮（≥98.0%）和（E）-茴香脑（≥99.0%）具有中等活性，LC50 值分别为 73.11ppm 和 102.41ppm。上述数据表明，主要化合物的相互作用可能在精油的毒性中发挥更重要的作用。
