De Keyser J, Ebinger G, Vauquelin G
Department of Neurology, Vrije Universiteit Brussel, Belgium.
Ann Neurol. 1990 Feb;27(2):157-61. doi: 10.1002/ana.410270210.
A deficiency of dopamine in the striatum may contribute to the decline in motor function associated with aging. We examined the effect of aging on the densities of the D1 and D2 dopamine receptors, their high-agonist affinity sites, and the dopamine uptake sites in postmortem human putamen (n = 32; age range, 19-88 years). With aging a steady decrease was seen in dopamine uptake sites (p less than 0.001), confirming previous morphometric and biochemical data of an age-related loss of nigrostriatal axons. In contrast, the concentrations of the D1 and D2 dopamine receptors and their high-agonist affinity sites, which are believed to represent the functionally active receptors, were not affected by the aging process. These results may have implications for the pharmacological treatment of the age-related decline in motor function.
纹状体内多巴胺缺乏可能导致与衰老相关的运动功能衰退。我们研究了衰老对死后人类壳核（n = 32；年龄范围19 - 88岁）中D1和D2多巴胺受体密度、其高激动剂亲和力位点以及多巴胺摄取位点的影响。随着衰老，多巴胺摄取位点呈稳定下降趋势（p < 0.001），这证实了先前关于黑质纹状体轴突随年龄减少的形态学和生化数据。相比之下，D1和D2多巴胺受体及其高激动剂亲和力位点的浓度（被认为代表功能活跃的受体）并未受衰老过程影响。这些结果可能对与年龄相关的运动功能衰退的药物治疗具有启示意义。
