猴子与人类衰老的功能及神经生物学相似性
Functional and neurobiological similarities of aging in monkeys and humans.
作者信息
Voytko M L
出版信息
Age (Omaha). 1997 Jan;20(1):29-44. doi: 10.1007/s11357-997-0003-3.
Aging in humans may be accompanied by alterations in several functional abilities. However, there is a great deal of individual variability in the functions that may be altered with age within and across aged people. One potential source of age-related behavioral variation may lie in a differential vulnerability of neurobiological systems to the aging process in particular individuals. Aged monkeys demonstrate behavioral and brain alterations that have many parallels with those observed in aged humans and are valuable animal models in which to investigate the interrelationships between age, behavior and neurobiological measures. This review outlines the similarities of functional and neurobiological aging in monkeys and humans, notes the variability that exists in both behavioral and neural systems in aging, and identifies some of the areas of aging that are in need of further investigation.
人类衰老可能伴随着多种功能能力的改变。然而，在老年人内部以及不同老年人之间，随着年龄增长可能发生改变的功能存在很大的个体差异。与年龄相关的行为变化的一个潜在来源可能在于神经生物学系统在特定个体中对衰老过程的不同易损性。老年猴子表现出的行为和大脑变化与在老年人类中观察到的变化有许多相似之处，是研究年龄、行为和神经生物学指标之间相互关系的有价值的动物模型。这篇综述概述了猴子和人类在功能和神经生物学衰老方面的相似性，指出了衰老过程中行为和神经系统中存在的变异性，并确定了一些需要进一步研究的衰老领域。
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