CdHgTe/CdS QDs 的特性研究及其在小鼠脊柱近红外荧光成像中的应用。
Characterization of CdHgTe/CdS QDs for near infrared fluorescence imaging of spinal column in a mouse model.
机构信息
Department of Biomedical Engineering, School of Life Science and Technology, China Pharmaceutical University, Nanjing, China.
出版信息
Photochem Photobiol. 2011 Jan-Feb;87(1):72-81. doi: 10.1111/j.1751-1097.2010.00828.x. Epub 2010 Nov 15.
Near infrared (NIR) CdHgTe/CdS quantum dots (QDs) were successfully prepared by a green synthetic route. The characteristics such as morphology, size, spectra, stability and toxicity were investigated in detail. The fluorescence wavelength of CdHgTe/CdS QDs could be adjusted to the NIR range (812nm), which made the in vivo NIR imaging possible. The in vivo dynamic biodistribution of CdHgTe/CdS QDs in a mouse model was monitored by an NIR imaging system. Results indicated that CdHgTe/CdS QDs with a diameter of about 5.8nm targeted to spinal column effectively. Further imaging of the dissected spine disclosed that QDs targeted to vertebra rather than spinal cord. The high fluorescence intensity together with targeting effect makes CdHgTe/CdS QDs particular candidates for imaging purposes in experimental animal models of vertebral injury.
近红外（NIR）CdHgTe/CdS 量子点（QDs）通过绿色合成路线成功制备。详细研究了其形态、尺寸、光谱、稳定性和毒性等特性。CdHgTe/CdS QDs 的荧光波长可调节至近红外范围（812nm），这使得体内近红外成象成为可能。通过近红外成象系统监测了 CdHgTe/CdS QDs 在小鼠模型中的体内动态生物分布。结果表明，直径约为 5.8nm 的 CdHgTe/CdS QDs 能有效地靶向脊柱。对解剖脊柱的进一步成像显示，QDs 靶向于椎体而不是脊髓。高荧光强度和靶向作用使 CdHgTe/CdS QDs 成为椎体损伤实验动物模型成像的理想候选物。
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