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鸡第 1 号染色体上骨骼性状数量性状位点的检测和精细定位。

Detection and fine mapping of quantitative trait loci for bone traits on chicken chromosome one.

机构信息

College of Animal Science and Technology, Northeast Agricultural University, Harbin, China.

出版信息

J Anim Breed Genet. 2010 Dec;127(6):462-8. doi: 10.1111/j.1439-0388.2010.00871.x. Epub 2010 Sep 22.

DOI:10.1111/j.1439-0388.2010.00871.x
PMID:21077970
Abstract

In broiler chickens, bone problems are an important welfare issue that has been linked to genetic selection for rapid growth. The objectives of this study were to identify and fine map quantitative trait loci (QTL) associated with bone traits. The Northeast Agricultural University resource population (NEAURP) being an F(2) population was used in this study, and a total of 17 bone traits were measured. In primary genome scan, the linkage map was constructed with 23 microsatellite markers across the entire chicken chromosome 1. Seventeen QTLs for bone traits were identified and 12 of these were found between LEI0079 and ROS0025 (50.8 cM apart). To fine map the QTLs located between LEI0079 and ROS0025, more markers and more individuals were used and a new partial linkage map was constructed. The confidence intervals for QTLs were sharply narrowed down from 24.5∼52.6 to 2.7∼17.0 Mb. This study identified chromosome regions harbouring significant QTLs affecting bone traits and showed that the use of more markers and individuals could decrease the confidence interval of QTL effectively. The results provide a useful reference for further candidate gene research and MAS for bone traits.

摘要

在肉鸡中，骨骼问题是一个重要的福利问题，与遗传选择快速生长有关。本研究的目的是鉴定和精细定位与骨骼特征相关的数量性状基因座 (QTL)。本研究使用了东北农业大学资源群体 (NEAURP)，这是一个 F(2) 群体，共测量了 17 个骨骼特征。在初步基因组扫描中，使用分布在整个鸡 1 号染色体上的 23 个微卫星标记构建了连锁图谱。鉴定出 17 个与骨骼特征相关的 QTL，其中 12 个位于 LEI0079 和 ROS0025 之间 (相距 50.8 cM)。为了精细定位位于 LEI0079 和 ROS0025 之间的 QTL，使用了更多的标记和个体，并构建了一个新的部分连锁图谱。QTL 的置信区间从 24.5∼52.6 显著缩小到 2.7∼17.0 Mb。本研究鉴定出了含有影响骨骼特征的重要 QTL 的染色体区域，并表明使用更多的标记和个体可以有效缩小 QTL 的置信区间。研究结果为进一步的候选基因研究和骨骼特征的 MAS 提供了有用的参考。