人软骨肉瘤的治疗性分子靶点。
Therapeutic molecular targets in human chondrosarcoma.
机构信息
Osteoarticular Research Group, Centre for Molecular Medicine, University of Edinburgh, Edinburgh, UK.
出版信息
Int J Exp Pathol. 2010 Oct;91(5):387-93. doi: 10.1111/j.1365-2613.2010.00749.x.
Abstract
Chondrosarcomas are malignant cartilage tumours. They are poorly responsive to chemotherapy and radiotherapy. Treatment is usually limited to surgical resection; however, survival of patients with high-grade chondrosarcoma is poor, even with wide surgical resection. Induction of apoptosis in chondrosarcoma cells, either directly or by enhancement of the response to chemotherapeutic drugs and radiation, may be a route by which outcome can be improved. In this article, we review potential molecular targets that regulate chondrocyte apoptosis and discuss the experimental evidence for their utility.
摘要
软骨肉瘤是一种恶性软骨肿瘤。它们对化疗和放疗的反应不佳。治疗通常限于手术切除；然而，即使进行广泛的手术切除，高级别软骨肉瘤患者的生存率仍然很差。在软骨肉瘤细胞中诱导细胞凋亡，无论是直接诱导还是增强对化疗药物和辐射的反应，都可能是改善预后的一种途径。在本文中，我们回顾了调节软骨细胞凋亡的潜在分子靶点，并讨论了它们的实用性的实验证据。
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