Laboratory of Mathematical Physics, Rockefeller University, 1230 York Avenue, New York, NY 10065, USA.
Philos Trans A Math Phys Eng Sci. 2010 Dec 28;368(1933):5597-603. doi: 10.1098/rsta.2010.0273.
Calcium signals participate in a large variety of physiological processes. In many instances, they involve calcium entry through inositol 1,4,5-trisphosphate (IP(3)) receptors (IP(3)Rs), which are usually organized in clusters. Recent high-resolution optical experiments by Smith & Parker have provided new information on Ca(2+) release from clustered IP(3)Rs. In the present paper, we use the model recently introduced by Solovey & Ponce Dawson to determine how the distribution of the number of IP(3)Rs that become open during a localized release event may change by the presence of Ca(2+) buffers, substances that react with Ca(2+), altering its concentration and transport properties. We then discuss how buffer properties could be extracted from the observation of local signals.
钙信号参与了大量的生理过程。在许多情况下，它们涉及通过肌醇 1,4,5-三磷酸 (IP(3)) 受体 (IP(3)R) 的钙内流，这些受体通常以簇的形式存在。Smith 和 Parker 的最近高分辨率光学实验提供了关于簇状 IP(3)R 中钙释放的新信息。在本文中，我们使用 Solovey 和 Ponce Dawson 最近提出的模型来确定在局部释放事件中，开放的 IP(3)R 的数量分布如何因 Ca(2+) 缓冲剂的存在而发生变化，这些缓冲剂与 Ca(2+) 反应，改变其浓度和传输特性。然后，我们将讨论如何从局部信号的观察中提取缓冲剂的特性。
