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[妊娠期的皮肤科治疗]

[Dermatologic therapy in pregnancy].

作者信息

Wohlrab J

机构信息

Universitätsklinik und Poliklinik für Dermatologie und Venerologie, Martin Luther Universität Halle-Wittenberg, Ernst-Kromayer-Str. 5, 06097, Halle.

出版信息

Hautarzt. 2010 Dec;61(12):1046-51. doi: 10.1007/s00105-010-2006-8.

DOI:10.1007/s00105-010-2006-8
PMID:21079902
Abstract

Pharmacologic therapy of a pregnant patient requires particular care in selecting the active substances to be used, their dosage and administration. The teratogenic risk and the therapeutic benefit must be carefully weighed for the mother and possibly also for the child, and attention paid to the special precautions and documentation obligations of off-label applications. This article addresses the general aspects of benefit-risk evaluation, provides an opinion on the teratogenic potency of dermatologically relevant medications, formulates recommendations for frequent general dermatological indications and lists additional possible information sources for special case constellations.

摘要

对孕妇进行药物治疗时,在选择使用的活性物质、其剂量和给药方式方面需要格外谨慎。必须仔细权衡对母亲以及可能对胎儿的致畸风险和治疗益处,并注意超说明书用药的特殊预防措施和记录义务。本文阐述了获益风险评估的一般方面,对皮肤科相关药物的致畸潜力发表意见,针对常见的一般皮肤科适应症制定建议,并列出特殊病例情况的其他可能信息来源。

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Safety of dermatologic medications in pregnancy and lactation: Part II. Lactation.妊娠期和哺乳期的皮肤科药物安全性:第二部分。哺乳期。
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Safety of dermatologic medications in pregnancy and lactation: Part I. Pregnancy.妊娠期和哺乳期皮肤病药物的安全性:第一部分。妊娠期。
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[Local treatment of skin diseases in pregnant women].[孕妇皮肤病的局部治疗]
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引用本文的文献

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[Drug therapy safety during pregnancy and breastfeeding].[孕期及哺乳期的药物治疗安全性]
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2
[Significance of therapy planning].[治疗计划的意义]
Hautarzt. 2014 Mar;65(3):218-20. doi: 10.1007/s00105-013-2660-8.

本文引用的文献

1
[S2k-guideline for therapy of acne].[严重寻常痤疮治疗的S2k指南]
J Dtsch Dermatol Ges. 2010 Jul;8 Suppl 2:s1-59. doi: 10.1111/j.1610-0387.2010.07466.x.
2
Development in the cynomolgus macaque following administration of ustekinumab, a human anti-IL-12/23p40 monoclonal antibody, during pregnancy and lactation.在孕期和哺乳期给予人源抗IL-12/23 p40单克隆抗体优特克单抗后食蟹猴的发育情况。
Birth Defects Res B Dev Reprod Toxicol. 2010 Oct;89(5):351-63. doi: 10.1002/bdrb.20250.
3
Systematic review of the safety of topical corticosteroids in pregnancy.
系统评价妊娠期外用皮质类固醇的安全性。
J Am Acad Dermatol. 2010 Apr;62(4):694-705. doi: 10.1016/j.jaad.2009.09.041. Epub 2010 Feb 1.
4
A safety assessment of tumor necrosis factor antagonists during pregnancy: a review of the Food and Drug Administration database.孕期肿瘤坏死因子拮抗剂的安全性评估:对美国食品药品监督管理局数据库的综述
J Rheumatol. 2009 Mar;36(3):635-41. doi: 10.3899/jrheum.080545.
5
[Antibiotic therapy in pregnancy].[孕期抗生素治疗]
Dtsch Med Wochenschr. 2008 Mar;133(11):511-5. doi: 10.1055/s-2008-1046742.
6
Effects of an anti-TNF-alpha monoclonal antibody, administered throughout pregnancy and lactation, on the development of the macaque immune system.在整个孕期和哺乳期给予抗TNF-α单克隆抗体对猕猴免疫系统发育的影响。
Am J Reprod Immunol. 2007 Aug;58(2):138-49. doi: 10.1111/j.1600-0897.2007.00499.x.
7
Physiological and biological skin changes in pregnancy.孕期皮肤的生理和生物学变化。
Clin Dermatol. 2006 Mar-Apr;24(2):80-3. doi: 10.1016/j.clindermatol.2005.10.002.
8
Minor malformations characteristic of the retinoic acid embryopathy and other birth outcomes in children of women exposed to topical tretinoin during early pregnancy.在妊娠早期接触外用维甲酸的女性所生儿童中,出现的维甲酸胚胎病特征性轻微畸形及其他出生结局。
Am J Med Genet A. 2005 Jul 15;136(2):117-21. doi: 10.1002/ajmg.a.30744.
9
Safety of hydroxychloroquine in pregnant patients with connective tissue diseases: a study of one hundred thirty-three cases compared with a control group.羟氯喹在患有结缔组织病的孕妇中的安全性:一项133例病例与对照组的比较研究。
Arthritis Rheum. 2003 Nov;48(11):3207-11. doi: 10.1002/art.11304.
10
Cyclophosphamide, methotrexate, and cytarabine embropathy: is apoptosis the common pathway?环磷酰胺、甲氨蝶呤和阿糖胞苷所致胚胎病:细胞凋亡是共同途径吗?
Birth Defects Res A Clin Mol Teratol. 2003 Jun;67(6):403-8. doi: 10.1002/bdra.10060.