Wohlrab J
Universitätsklinik und Poliklinik für Dermatologie und Venerologie, Martin Luther Universität Halle-Wittenberg, Ernst-Kromayer-Str. 5, 06097, Halle.
Hautarzt. 2010 Dec;61(12):1046-51. doi: 10.1007/s00105-010-2006-8.
Pharmacologic therapy of a pregnant patient requires particular care in selecting the active substances to be used, their dosage and administration. The teratogenic risk and the therapeutic benefit must be carefully weighed for the mother and possibly also for the child, and attention paid to the special precautions and documentation obligations of off-label applications. This article addresses the general aspects of benefit-risk evaluation, provides an opinion on the teratogenic potency of dermatologically relevant medications, formulates recommendations for frequent general dermatological indications and lists additional possible information sources for special case constellations.
对孕妇进行药物治疗时,在选择使用的活性物质、其剂量和给药方式方面需要格外谨慎。必须仔细权衡对母亲以及可能对胎儿的致畸风险和治疗益处,并注意超说明书用药的特殊预防措施和记录义务。本文阐述了获益风险评估的一般方面,对皮肤科相关药物的致畸潜力发表意见,针对常见的一般皮肤科适应症制定建议,并列出特殊病例情况的其他可能信息来源。