白细胞介素-4对人外周血淋巴细胞中IgG4和IgE合成的诱导作用。
The inductive effect of interleukin-4 on IgG4 and IgE synthesis in human peripheral blood lymphocytes.
作者信息
Ishizaka A, Sakiyama Y, Nakanishi M, Tomizawa K, Oshika E, Kojima K, Taguchi Y, Kandil E, Matsumoto S
机构信息
Department of Paediatrics, Hokkaido University School of Medicine, Sapporo, Japan.
出版信息
Clin Exp Immunol. 1990 Mar;79(3):392-6. doi: 10.1111/j.1365-2249.1990.tb08101.x.
Abstract
Using murine monoclonal antibodies against human IgG subclasses, specific and sensitive ELISAs assay to quantify the four human IgG subclasses in cell culture supernatants were established. The effect of human recombinant interleukin-4 (IL-4) on the regulation of IgG subclasses by normal peripheral blood lymphocytes was investigated. In addition to the enhancement of IgE synthesis, IL-4 preferentially induced IgG4 synthesis in vitro, whereas IL-4 had no effect on IgG1, IgG2, and IgG3 synthesis. IL-4-induced IgG4 production was blocked in a dose-dependent manner by recombinant interferon-gamma and anti-human IL-4 monoclonal antibody. Collectively, this data indicates that IL-4 plays an important regulatory role in both IgG subclass and IgE synthesis.
摘要
利用抗人IgG亚类的鼠单克隆抗体，建立了特异性和灵敏的酶联免疫吸附测定法（ELISA），以定量细胞培养上清液中的四种人IgG亚类。研究了重组人白细胞介素-4（IL-4）对正常外周血淋巴细胞调节IgG亚类的作用。除增强IgE合成外，IL-4在体外优先诱导IgG4合成，而对IgG1、IgG2和IgG3合成无影响。重组干扰素-γ和抗人IL-4单克隆抗体以剂量依赖方式阻断IL-4诱导的IgG4产生。总体而言，这些数据表明IL-4在IgG亚类和IgE合成中均起重要调节作用。
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