Department of Chest Disease, Medical Faculty, Dicle University, Diyarbakir, Turkey.
Biol Trace Elem Res. 2011 Nov;143(2):659-67. doi: 10.1007/s12011-010-8897-5. Epub 2010 Nov 16.
Severity of chronic obstructive pulmonary disease (COPD) exacerbation is associated with increased level of copper (Cu), zinc (Zn), and lipid peroxidation (malodialdehyde, MDA). The aim of this study was to investigate the levels of lipid peroxidation, Coenzyme Q10 (CoQ10), Zn, and Cu in the COPD exacerbations. Forty-five patients with COPD acute exacerbation and 45 healthy smokers as control group were used in the study. Forced expiratory volume in 1 s (FEV1) and forced vital capacity (FVC) were lower in exacerbation group than in control. C- reactive protein levels, white blood cell count, and sedimentation rate were significantly (p<0.001) higher in patients than in control. CoQ10 level and Cu/Zn ratio was significantly (p<0.05) lower in patients than in control, although MDA, Cu, and Zn levels were significantly (p<0.05) higher in patients than in control. Negative correlations were found among MDA, Cu, Zn, FEV1, and FVC values in exacerbation and control subjects (p<0.05). In conclusion, we observed that oxidative stress in the exacerbation period of COPD patients was increased. The decrease in CoQ10 level and Cu/Zn ratio and elevation in Cu and Zn levels observed in the patients probably result from the defense response of organism and are mediated by inflammatory-like substances.
慢性阻塞性肺疾病（COPD）加重的严重程度与铜（Cu）、锌（Zn）和脂质过氧化（丙二醛，MDA）水平的升高有关。本研究的目的是研究 COPD 加重时脂质过氧化、辅酶 Q10（CoQ10）、Zn 和 Cu 的水平。研究中使用了 45 例 COPD 急性加重患者和 45 例健康吸烟者作为对照组。与对照组相比，加重组的 1 秒用力呼气量（FEV1）和用力肺活量（FVC）较低。与对照组相比，患者的 C-反应蛋白水平、白细胞计数和沉降率显著升高（p<0.001）。尽管 MDA、Cu 和 Zn 水平显著升高（p<0.05），但患者的 CoQ10 水平和 Cu/Zn 比值显著降低（p<0.05）。在加重和对照组患者中，MDA、Cu、Zn、FEV1 和 FVC 值之间存在负相关（p<0.05）。总之，我们观察到 COPD 患者加重期的氧化应激增加。患者中观察到的 CoQ10 水平降低和 Cu/Zn 比值升高以及 Cu 和 Zn 水平升高可能是机体防御反应的结果，并由类似炎症的物质介导。
