Department of Oriental Pharmacy, College of Pharmacy and Wonkwang-Oriental Medicines Research Institute, Wonkwang University, Iksan, Jeonbuk, Republic of Korea.
Immunopharmacol Immunotoxicol. 2011 Jun;33(2):266-70. doi: 10.3109/08923973.2010.499914. Epub 2010 Nov 16.
Sinomenine is an alkaloid compound and a prominent anti-allergic agent found in the root of the climbing plant Sinomenium acutum. However, its effects on the bone marrow-derived mast cell (BMMC) mediated allergy and inflammation mechanism remain unknown. In this study, the biological effects of sinomenine were evaluated while focusing on its effects on the allergic mediator in PMA plus A23187-stimulated BMMCs. An investigation was also conducted to determine its effects on the production of several allergic mediators including interleukin-6 (IL-6), prostaglandin D(2) (PGD(2)), leukotriene C(4) (LTC(4)), β-Hexosaminidase (β-Hex), and cyclooxygenase-2 (COX-2) protein. The results revealed that sinomenine inhibited the PMA plus A23187-induced production of IL-6, PGD(2), LTC(4), β-Hex, and COX-2 protein. Taken together, these findings indicate that sinomenine has the potential for use in the treatment of allergy.
青藤碱是一种生物碱化合物，是从青风藤中提取的一种主要的抗过敏药物。然而，其对骨髓来源的肥大细胞（BMMC）介导的过敏和炎症机制的影响尚不清楚。在这项研究中，我们评估了青藤碱的生物学效应，重点研究了其对 PMA 加 A23187 刺激的 BMMC 中过敏介质的影响。还研究了其对几种过敏介质（包括白细胞介素 6（IL-6）、前列腺素 D2（PGD2）、白三烯 C4（LTC4）、β-己糖胺酶（β-Hex）和环加氧酶-2（COX-2）蛋白）的产生的影响。结果表明，青藤碱抑制了 PMA 加 A23187 诱导的 IL-6、PGD2、LTC4、β-Hex 和 COX-2 蛋白的产生。综上所述，这些发现表明青藤碱有可能用于治疗过敏。
