姬松茸提取物对骨髓来源肥大细胞的抗炎和抗过敏作用。
Anti-inflammatory and anti-allergic effect of Agaricus blazei extract in bone marrow-derived mast cells.
机构信息
Immune Modulator Research Center, Bio-Therapeutics Research Institute, Korea Research Institute of Bioscience and Biotechnology, ChungBuk, Korea.
出版信息
Am J Chin Med. 2012;40(5):1073-84. doi: 10.1142/S0192415X12500796.
In this study, the anti-inflammatory and anti-allergic effects of the chloroform-soluble extract of Agaricus blazei in mouse bone marrow-derived mast cells (BMMCs) were investigated. The chloroform-soluble extract inhibited IL-6 production in PMA plus A23187-stimulated BMMCs, and down-regulated the phosphorylation of Akt. In addition, this extract demonstrated inhibition of the degranulation of β-hexosaminidase and the production of IL-6, prostaglandin D(2) and leukotriene C(4) in PMA plus A23187-induced BMMCs. In conclusion, the chloroform-soluble extract of Agaricus blazei exerted anti-inflammatory and anti-allergic activities mediated by influencing IL-6, prostaglandin D(2), leukotriene C(4), and the phosphorylation of Akt.
在这项研究中，研究了灵芝氯仿可溶提取物对鼠骨髓来源肥大细胞（BMMCs）的抗炎和抗过敏作用。氯仿可溶提取物抑制了 PMA 加 A23187 刺激的 BMMCs 中白细胞介素 6（IL-6）的产生，并下调了 Akt 的磷酸化。此外，该提取物还抑制了 PMA 加 A23187 诱导的 BMMCs 中β-己糖胺酶的脱颗粒以及白细胞介素 6（IL-6）、前列腺素 D(2)和白三烯 C(4)的产生。综上所述，灵芝氯仿可溶提取物通过影响白细胞介素 6（IL-6）、前列腺素 D(2)、白三烯 C(4)和 Akt 的磷酸化发挥抗炎和抗过敏作用。
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