心肌梗死后左心室心肌细胞重构：大鼠存在性别差异吗？
Post-myocardial infarction left ventricular myocyte remodeling: are there gender differences in rats?
机构信息
Cardiovascular Health Research Center, Sanford Research/University of South Dakota, 1100 East 21st Street, Suite 700, Sioux Falls, SD 57105, USA.
出版信息
Cardiovasc Pathol. 2011 Sep-Oct;20(5):e189-95. doi: 10.1016/j.carpath.2010.09.007. Epub 2010 Nov 16.
Abstract
BACKGROUND
Previous studies have shown gender differences in left ventricular remodeling after myocardial infarction. Results are varied, however, and reliable, comprehensive data for changes in cardiac myocyte shape are not available.
METHODS
Young adult female and male Sprague-Dawley rats were used in this study and randomly assigned to the myocardial infarction and sham myocardial infarction groups. Myocardial infarction was produced by ligation of the left descending coronary artery. Four weeks after surgery, left ventricular echocardiography and hemodynamics were performed before isolating myocytes for size determination.
RESULTS
In general, left ventricular functional changes after myocardial infarction were comparable. Females developed slightly, but significantly, more left ventricular hypertrophy than males, and this was reflected by the relative increases in left ventricular myocyte volume. In both males and females, however, myocyte hypertrophy was due exclusively to lengthening of myocytes with no change in myocyte cross-sectional area.
CONCLUSIONS
This study demonstrates that post-myocardial infarction changes in LV function and myocyte remodeling are remarkably similar in young adult male and female rats.
摘要
背景
先前的研究表明，心肌梗死后左心室重构存在性别差异。然而，结果存在差异，并且缺乏关于心肌细胞形状变化的可靠、全面的数据。
方法
本研究使用年轻成年雌性和雄性 Sprague-Dawley 大鼠，并将其随机分配到心肌梗死和假心肌梗死组。通过结扎左冠状动脉下降支来制造心肌梗死。手术后 4 周，进行左心室超声心动图和血液动力学检查，然后分离心肌细胞以确定大小。
结果
一般来说，心肌梗死后左心室功能的变化是可比的。与男性相比，女性的左心室肥厚程度略高，但差异显著，这反映在左心室心肌细胞体积的相对增加上。然而，在男性和女性中，心肌细胞肥大仅归因于心肌细胞的延长，而心肌细胞横截面积没有变化。
结论
本研究表明，年轻成年雄性和雌性大鼠的心肌梗死后 LV 功能和心肌细胞重构的变化非常相似。
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