Department of Preventive Medicine, Keck School of Medicine, Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, CA 90089-9175, USA.
Carcinogenesis. 2011 Feb;32(2):197-202. doi: 10.1093/carcin/bgq233. Epub 2010 Nov 15.
Genome-wide association studies have associated common variations at chromosomes 5p15 and 15q25 with lung cancer risk. The 5p15 locus has also been associated with increased bladder cancer risk in a recent report. The 15q25 locus has been associated with nicotine dependence and self-reported number of cigarettes smoked per day in some studies and it was proposed that its association with lung cancer may be mediated through differences in smoking behavior. Here, we investigated the roles of variations at 5p15 (rs401681, rs402710, rs2736098 and rs2736100) and 15q25 (rs1051730 and rs8034191) in bladder cancer etiology in two case-control studies conducted separately in Los Angeles County, CA, USA (498 cases and 588 controls) and in Shanghai, China (506 cases and 530 controls). We replicated the association between the 5p15 locus and bladder cancer among non-Hispanic whites (NHW) in Los Angeles [for rs2736100, per C allele odds ratio (OR) = 1.23; 95% confidence interval (CI), 1.02-1.48; P = 0.029] and among Chinese in Shanghai (OR = 1.22; 95% CI, 1.02-1.47; P = 0.033). Both rs1051730 and rs8034191 at 15q25 were rare among Chinese. Among NHW, a significant association was found between rs8034191 and bladder cancer which persisted after adjustment for cigarette smoking status, number of cigarettes smoked per day and number of years of smoking (per C allele OR = 1.26; 95% CI, 1.04-1.54; P = 0.017). Our results support 5p15 and 15q25 as susceptibility regions for bladder cancer risk.
全基因组关联研究已将染色体 5p15 和 15q25 上的常见变异与肺癌风险联系起来。最近的一份报告还表明，5p15 位点也与膀胱癌风险增加有关。15q25 位点与一些研究中的尼古丁依赖和每日吸烟支数有关，有人提出，其与肺癌的关联可能是通过吸烟行为的差异介导的。在这里，我们在两项分别在美国加利福尼亚州洛杉矶县（498 例病例和 588 例对照）和中国上海（506 例病例和 530 例对照）进行的病例对照研究中，调查了 5p15（rs401681、rs402710、rs2736098 和 rs2736100）和 15q25（rs1051730 和 rs8034191）变异在膀胱癌病因学中的作用。我们复制了 5p15 位点与洛杉矶非西班牙裔白人（NHW）中膀胱癌之间的关联[对于 rs2736100，每个 C 等位基因的比值比（OR）=1.23；95%置信区间（CI），1.02-1.48；P=0.029]和上海的中国人之间的关联（OR=1.22；95%CI，1.02-1.47；P=0.033）。15q25 上的 rs1051730 和 rs8034191 在中国人中都很少见。在 NHW 中，rs8034191 与膀胱癌之间存在显著关联，这种关联在调整吸烟状况、每日吸烟支数和吸烟年限后仍然存在（每个 C 等位基因的 OR=1.26；95%CI，1.04-1.54；P=0.017）。我们的结果支持 5p15 和 15q25 作为膀胱癌风险的易感区域。
