Department of Otolaryngology and Laryngological Oncology, Pomeranian Medical University, Szczecin, Poland.
PLoS One. 2011;6(9):e25057. doi: 10.1371/journal.pone.0025057. Epub 2011 Sep 22.
Genetic factors associated with the risk of smoking related cancers have until recently remained elusive. Since the publication of a genome-wide association study (GWAS) on lung cancer new genetic loci have been identified that appear to be associated with disease risk. In this replication study we genotyped 14 single nucleotide polymorphisms (SNPs) located at the 5p12.3-p15.33, 6p21.3-p22.1, 6q23-q27 and 15q25.1 loci in 874 lung, 450 bladder, 418 laryngeal cancer cases and cancer-free controls, matched by year of birth and sex to the cases. Our results revealed that loci in the chromosome region 15q25.1 (rs16969968[A], rs8034191[G]) and 5p15 (rs402710[T]) are associated with lung cancer risk in the Polish population (smoking status adjusted OR = 1.45, 1.35, 0.77; p ≤ 0.0001, 0.0005, 0.002; 95%CI 1.23-1.72, 1.14-1.59, 0.66-0.91 respectively). None of the other regions analyzed herein were implicated in the risk of lung, bladder or laryngeal cancer. This study supports previous findings on lung cancer but fails to show association of SNPs located in 15q25.1 and 5p15 region with other smoking related cancers like bladder and laryngeal cancer.
遗传因素与吸烟相关癌症的风险有关，但直到最近仍然难以捉摸。自肺癌全基因组关联研究（GWAS）发表以来，已经确定了新的遗传位点，这些位点似乎与疾病风险相关。在这项复制研究中，我们对位于 5p12.3-p15.33、6p21.3-p22.1、6q23-q27 和 15q25.1 基因座的 14 个单核苷酸多态性（SNP）进行了基因分型，这些基因座位于 874 例肺癌、450 例膀胱癌、418 例喉癌病例和按出生年份和性别与病例相匹配的无癌症对照中。我们的研究结果表明，染色体区域 15q25.1（rs16969968[A]，rs8034191[G]）和 5p15（rs402710[T]）中的位点与波兰人群的肺癌风险相关（调整后的吸烟状况 OR = 1.45、1.35、0.77；p ≤ 0.0001、0.0005、0.002；95%CI 1.23-1.72、1.14-1.59、0.66-0.91）。在此分析的其他区域均未涉及肺癌、膀胱癌或喉癌的风险。本研究支持以前关于肺癌的研究结果，但未能显示位于 15q25.1 和 5p15 区域的 SNP 与其他与吸烟相关的癌症（如膀胱癌和喉癌）的风险相关。
