Juettemann Thomas, Gerloff Dietlind L
School of Biology, University of Edinburgh, Edinburgh EH9 3JJ, UK.
Nucleic Acids Res. 2011 Jan;39(Database issue):D705-11. doi: 10.1093/nar/gkq859. Epub 2010 Nov 16.
Binary subcomplexes in proteins database (BISC) is a new protein-protein interaction (PPI) database linking up the two communities most active in their characterization: structural biology and functional genomics researchers. The BISC resource offers users (i) a structural perspective and related information about binary subcomplexes (i.e. physical direct interactions between proteins) that are either structurally characterized or modellable entries in the main functional genomics PPI databases BioGRID, IntAct and HPRD; (ii) selected web services to further investigate the validity of postulated PPI by inspection of their hypothetical modelled interfaces. Among other uses we envision that this resource can help identify possible false positive PPI in current database records. BISC is freely available at http://bisc.cse.ucsc.edu.
蛋白质数据库中的二元亚复合物（BISC）是一个新的蛋白质-蛋白质相互作用（PPI）数据库，它连接了在蛋白质特征描述方面最活跃的两个群体：结构生物学和功能基因组学研究人员。BISC资源为用户提供：（i）关于二元亚复合物（即蛋白质之间的物理直接相互作用）的结构视角及相关信息，这些二元亚复合物在主要的功能基因组学PPI数据库BioGRID、IntAct和HPRD中要么具有结构特征，要么是可建模的条目；（ii）选定的网络服务，通过检查假设的建模界面来进一步研究假定的PPI的有效性。在其他用途中，我们设想该资源有助于识别当前数据库记录中可能的假阳性PPI。BISC可在http://bisc.cse.ucsc.edu免费获取。
