Williamson J R, Ostrow E, Eades D, Chang K, Allison W, Kilo C, Sherman W R
Department of Pathology, Washington University School of Medicine, St. Louis, Missouri 63110.
J Clin Invest. 1990 Apr;85(4):1167-72. doi: 10.1172/JCI114549.
Exposure of skin chamber granulation tissue vessels in nondiabetic rats to 11 or 15 mM D-glucose (but not L-glucose or 3-O-methylglucose) twice daily for 10 d induces vascular functional changes (increased albumin permeation and blood flow) identical to those in animals with mild or severe streptozotocin diabetes, respectively. These vascular changes are strongly linked to increased metabolism of glucose via the sorbitol pathway and are independent of nonenzymatic glycosylation as well as systemic metabolic and hormonal imbalances associated with the diabetic milieu. (J. Clin. Invest. 1990. 85:1167-1172.)
将非糖尿病大鼠皮肤腔室肉芽组织血管每天两次暴露于11或15 mM D-葡萄糖（而非L-葡萄糖或3-O-甲基葡萄糖）中，持续10天，会诱导出与轻度或重度链脲佐菌素糖尿病动物相同的血管功能变化（白蛋白渗透增加和血流量增加）。这些血管变化与通过山梨醇途径增加的葡萄糖代谢密切相关，并且独立于非酶糖基化以及与糖尿病环境相关的全身代谢和激素失衡。（《临床研究杂志》1990年。85:1167 - 1172。）
