Ernest J T, Goldstick T K, Engerman R L
Invest Ophthalmol Vis Sci. 1983 Jul;24(7):985-9.
Preretinal oxygen tensions were measured continuously using microelectrodes in four normal dogs and four dogs made diabetic with alloxan. The latter were kept under poor control for 8 months. Glucose administered intravenously in 30 to 90 sec to all the dogs when they were normoglycemic caused an immediate increase in preretinal oxygen tension lasting approximately 10 min. When the dogs were given 100% oxygen to breathe, their preretinal oxygen tensions increased. This increase in preretinal oxygen tension was 36.6 +/- 8.5 mmHg (+/-SE) when the animals were normoglycemic and 63.5 +/- 9.2 mmHg when the animals were made hyperglycemic. This suggests that hyperglycemia impairs oxygen autoregulation. Moreover, the diabetic dogs appeared to exhibit a larger preretinal oxygen tension increase than normal dogs when both were given 100% oxygen to breathe. The small number of animals studied, however, makes a comparison between the two groups difficult. These data lead one to speculate that in diabetes there may be an impairment of the normal retinal vascular homeostasis. This could play a role in both the development and in the severity of diabetic retinopathy.
使用微电极连续测量了4只正常犬和4只用四氧嘧啶诱导糖尿病的犬的视网膜前氧张力。后一组犬的血糖控制不佳达8个月。当所有犬血糖正常时，在30至90秒内静脉注射葡萄糖会使视网膜前氧张力立即升高，持续约10分钟。当给犬吸入100%氧气时，它们的视网膜前氧张力会升高。当动物血糖正常时，这种视网膜前氧张力的升高为36.6±8.5 mmHg（±标准误），当动物血糖升高时为63.5±9.2 mmHg。这表明高血糖会损害氧的自动调节。此外，当给正常犬和糖尿病犬都吸入100%氧气时，糖尿病犬的视网膜前氧张力升高似乎比正常犬更大。然而，所研究的动物数量较少，使得两组之间的比较存在困难。这些数据让人推测，在糖尿病中，正常的视网膜血管稳态可能受到损害。这可能在糖尿病视网膜病变的发生和严重程度中都起作用。
