房间里的大象：基于 microRNA 的疗法对于脑肿瘤（如胶质母细胞瘤）有现实的成功机会吗？
The elephant in the room: do microRNA-based therapies have a realistic chance of succeeding for brain tumors such as glioblastoma?
机构信息
Neuro-Oncology Division, Neurology Department, University of Virginia, Charlottesville, VA, USA.
出版信息
J Neurooncol. 2011 Jul;103(3):429-36. doi: 10.1007/s11060-010-0449-5. Epub 2010 Nov 17.
Abstract
It seems quite clear that microRNAs play important roles in neuro-oncology, as they do across perhaps all areas in biology. With recent advances in detecting and quantifying microRNAs in tissue and serum, it appears increasingly likely that microRNAs will be clinically useful as biomarkers for brain tumors and other cancers. Applying microRNAs for treatment of brain tumors poses greater hurdles by far, however, and despite promising in vitro results this may never become a reality. This review fits recent advances into a framework for considering the potential of microRNAs for brain tumor therapy, considering the power of individual microRNAs, delivery issues, and indirect microRNA-based therapies.
摘要
很明显，miRNAs 在神经肿瘤学中发挥着重要作用，就像它们在生物学的所有领域中一样。随着在组织和血清中检测和定量 miRNAs 的最新进展，miRNAs 作为脑肿瘤和其他癌症的生物标志物似乎越来越有用。然而，将 miRNAs 应用于脑瘤治疗存在更大的障碍，尽管体外结果很有前景，但这可能永远不会成为现实。这篇综述将最近的进展纳入一个框架，考虑了 miRNAs 在脑肿瘤治疗中的潜力，考虑了单个 miRNAs 的作用、传递问题和间接基于 miRNAs 的治疗。
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